Stearic acid, monoester with propane-1,2-diol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

other: weight of evidence

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Weight of Evidence (WoE) assessment based on structural analogues and hydrolysis products

Justification for type of information:

No data on the ecotoxicity are available for Stearic acid, monoester with propane-1,2-diol. The ecotoxicity of this substance is therefore assessed in a weight of evidence analysis based on existing data on similar compounds and hydrolysis products. See the attached report.
The environmental toxicity to invertebrates is assessed based on existing data on:
- the group of fatty acid esters (C10-C18),
- the relevant hydrolysis products including the group of fatty acids and propane-diol.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test data used in the weight of evidence analysis are results from studies performed according to standard guidelines.

GLP compliance:

no

Test organisms (species):

Daphnia magna

Water media type:

freshwater

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.2 mg/L

Remarks on result:

other: It is to be noted that all short-term effect concentrations are above the estimated water solubility of 0.0062 mg/L at 25 °C

Validity criteria fulfilled:

not applicable

Conclusions:

Based on a weight of evidence approach the substance is concluded to have a short-term toxicity (48h EC50) to crustaceans of 1.8 mg/L

Executive summary:

Data on this endpoint are not available for “Stearic acid, monoester with propane-1,2-diol”. The environmental toxicity of this UVCB substance is therefore assessed in the present weight of evidence analysis based on existing data on:

-       the group of fatty acid esters (C10-C18),

-       the relevant hydrolysis products including the group of fatty acids and propane-diol,

-       QSAR predictions for main components (monoesters and diesters of propane-diols).

Hereby, a solid data set is available for deriving a conclusion on the environmental toxicity of the UVCB-substance.

As the substance is an UVCB-substance, and as expert assessments of substances with similar properties and structure in addition to assessments of the components in the substance and the hydrolysis products are considered the most valid method for the assessment of the environmental toxicity of the UVCB substance, an overall weight of evidence approach is used for the assessment.

Based on a weight of evidence approach the substance is concluded to have a toxicity to crustaceans of 1.8 mg/L

Description of key information

Based on a weight of evidence approach the substance is concluded to have a short-term toxicity (48h EC50) to crustaceans of 1.8 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.8 mg/L