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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

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Endpoint:
water solubility
Type of information:
other: data from database
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The National Institute of Technology and Evaluation (NITE) is referring to the CRC Handbook 84th ed. A reliability code of 2 is assigned to data from recognized reference handbooks / data collections.
Reason / purpose for cross-reference:
reference to other study
Guideline:
other: no data
GLP compliance:
not specified
Type of method:
other: no data
Water solubility:
0.2 vol%
Temp.:
25 °C
pH:
> 0 - < 14

No details given on the pH during the emasurement. It is assumed that the emasurement was done within around the neutral pH range.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 0.2% (2000 mg/l) at 25 °C. The test item therefore is regarded as "slightly soluble".
Executive summary:

The National Institute of Technology and Evaluatuion (NITE, Japan) is referring to the CRC Handbook 84th ed. A reliability code of 2 is assigned to data. 1,2,3-Trichloropropane has a water solubility of 0.2% (2000 mg/l) at 25 °C. The test item therefore is regarded as "slightly soluble".

Endpoint:
water solubility
Type of information:
other: data from data base
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The 2004 SIDS dossier is referring to the IUPAC-NIST Solubility Database. A reliability code of 2 is assigned to data from recognized reference handbooks / collection of data.
Guideline:
other: no data
Principles of method if other than guideline:
Data taken from database, no details on methodology given.
GLP compliance:
not specified
Type of method:
other: Data taken from database, no details on methodology given.
Water solubility:
1 880 mg/L
Temp.:
20 °C
pH:
>= 0 - <= 14
Water solubility:
2 010 mg/L
Temp.:
25 °C
pH:
>= 0 - <= 14

No details given on the pH during the measurement. It is assumed that the measurement was done approximately at neutral pH.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".
Executive summary:

The 2004 SIDS dossier is referring to the water solubility data given in the IUPAC-NIST Solubility Database. The IUPAC-NIST Solubility Database itself uses the average water solubilities reported by three different studies. Based on this, 1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".

Endpoint:
water solubility
Type of information:
other: data from database
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The 2004 SIDS dossier is referring to a study of Albanese (1987) on the determination of water solubility on 1,2,3-Trichloropropane. In the SIDS dossier a Klimisch-4-rating is given for this study. However, the "Hazardous Substances Data Bank" of the National Library of Medicine is a database referring to the same study of Albanese as "peer reviewed". Therefore all in all a Klimisch-2-score deems to be justified.
Guideline:
other: no data
Principles of method if other than guideline:
Data taken from database, no details on methodology given.
GLP compliance:
not specified
Type of method:
other: no data
Water solubility:
1 750 mg/L
Temp.:
25 °C
pH:
>= 0 - <= 14

No details given on the pH during the measurement. It is assumed that the measurement was done within around the neutral pH range.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 25 °C. The test item therefore is regarded as "slightly soluble".
Executive summary:

The 2004 SIDS dossier is referring to the water solubility data given by a study of Albanese 1987. The "Hazardous Substances Data Bank" of the National Library of Medicine is a database referring to the same study of Albanese as "peer reviewed", thus a Klimisch-2 -score was applied. According to Albanese, 1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 25 °C. The test item therefore is regarded as "slightly soluble".

Endpoint:
water solubility
Type of information:
other: data for handbook
Adequacy of study:
weight of evidence
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The 2004 SIDS dossier is referring to handbook data. A reliability code of 2 is assigned to data from recognized reference handbooks.
Guideline:
other: no data
Type of method:
other: no data
Water solubility:
1 750 mg/L
Temp.:
20 °C
pH:
>= 0 - <= 14

No details given on the pH during the measurement. It is assumed that the measurement was done within around the neutral pH range.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".
Executive summary:

The 2004 SIDS dossier is referring to handbook data of Riddick 1986. The Klimisch score is 2. According to Riddick, 1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".

Description of key information

Based on a weight of evidence approach, 1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C and of 2010 mg/l at 25 °C.

Key value for chemical safety assessment

Water solubility:
1 880 mg/L
at the temperature of:
20 °C

Additional information

Compilation of water solubility data on 1,2,3 -Trichloropropane

 Data source Water solubility in mg/l  Temperature °C 
SIDS dossier 2004 / IUPAC-NIST Solubility Database

1880 

20 

 SIDS dossier 2004 / IUPAC-NIST Solubility Database 

 2010

 25

 SIDS dossier 2004 / Albanese 1987 

1750 

 25

  SIDS dossier 2004 / Riddick 1986 

 1750

 20
NITE 2009 / CRC Handbook 84th ed.  2000  25 

The water solubility data reported on 1,2,3 -Trichloropropane are quite consistent (see above table) and the data set therefore considered as robust (all data Klimisch 2). Highlighted are the values 1880 mg/l at 20 °C and 2010 mg/l at 25 °C, as taken from the IUPAC-NIST Solubility Database, and as suggested in the 2004 SIDS dossier.