Registration Dossier
Registration Dossier
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EC number: 202-431-1 | CAS number: 95-55-6
Endpoint summary
Administrative data
Description of key information
According several non-GLP, non-OECD guideline studies, the substance did not cause corrosion or irritation on skin. Slight effects on eyes were reversible within 24h. Thus, the substance is regarded as non-irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Neat o-aminophenol as well as a 1% solution in propylene glycol applied to the clipped skin of rabbits was non-irritant. A 1% solution in propylene glycol was found slightly irritant to the rabbit eye one hour after instillation without rinsing. The effect was reversible within 24 hours.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as irritating for skin or eyes under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for irritation under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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