Registration Dossier
Registration Dossier
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EC number: 201-069-1 | CAS number: 77-92-9
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Information on method and guideline not stated
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.13
- Temp.:
- 25 °C
- No.:
- #2
- pKa:
- 4.76
- Temp.:
- 25 °C
- No.:
- #3
- pKa:
- 6.4
- Temp.:
- 25 °C
- Conclusions:
- pKa values of 3.13, 4.76 and 6.4 at 25°C were reported in a handbook which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.
Reference
Description of key information
pKa: 3.13, 4.76 and 6.4 at 25°C
Key value for chemical safety assessment
Additional information
Citric acid has three ionisable carboxylic acid groups. pKa values of 3.13, 4.76 and 6.4 at 25°C were reported in a handbook which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable and is selected as key study.
In a secondary source (Serjeant 1979) to which reliability could not be assigned, dissociation constant values of 2.79, 4.30 and 5.65 were reported for the substance.
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