Registration Dossier
Registration Dossier
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EC number: 202-613-0 | CAS number: 97-86-9
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
- Principles of method if other than guideline:
- 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazorium bromide (MTT) assay; the cytotoxic effect of i-BMA on the cell viability of carcinoma cell line derived from salivary gland (HSG cells) and human gingval fibroblasts (HGF cells) was determined. With these cells the cytotoxic activity and the
Ca2+ mobilization activity stimulated by various monomers was investigated. - GLP compliance:
- not specified
- Type of method:
- in vitro
Test material
- Reference substance name:
- Isobutyl methacrylate
- EC Number:
- 202-613-0
- EC Name:
- Isobutyl methacrylate
- Cas Number:
- 97-86-9
- Molecular formula:
- C8H14O2
- IUPAC Name:
- isobutyl methacrylate
- Details on test material:
- - Supplier: Tokyo Kasei Chem. Co., Tokyo, Japan
- Purity: commercial grade, no further purification
Constituent 1
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
Results and discussion
- Details on results:
- The cytotoxic effect of i-BMA on the cell viability of HSG cells was CC50: 0.010 mM and 0.013 mM (HGF cells) (cytotoxic concentration for 50 % cell death).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
