Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-993-8 | CAS number: 7398-69-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles but pre-dates GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- To investigate the oral absorption, distribution, and excretion of diallyldimethylammonium chloride into blood, urine, faeces, expired air and selected tissues in rats.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diallyldimethylammonium chloride
- EC Number:
- 230-993-8
- EC Name:
- Diallyldimethylammonium chloride
- Cas Number:
- 7398-69-8
- Molecular formula:
- C8H16N.Cl
- IUPAC Name:
- diallyldimethylammonium chloride
- Details on test material:
- - Name of test material (as cited in study report): C14 Dimethyldiallylammonium chloride
- Physical state: white crystalline solid
- Analytical purity: >99%
- Impurities (identity and concentrations): none
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling): no data
- Specific activity (if radiolabelling): 0.68 mC/g
- Locations of the label (if radiolabelling): no data
- Expiration date of radiochemical substance (if radiolabelling): no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 113-252g
- Fasting period before study: no
- Housing: Roth metabolism chambers
- Individual metabolism cages: yes
- Diet (e.g. ad libitum): dried Purina Rat chow combined with raw egg
- Water : ad libitum
- Acclimation period: two days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- Animals were treated with 656 mg/kg (24 hours); 1585 mg/kg (48 hours) or 1591 mg/kg (72 hours) of C14 DADMAC (100 microcuries/ml: 100 microcuries/1.9 grams.)
- No. of animals per sex per dose / concentration:
- One
- Control animals:
- no
- Positive control reference chemical:
- no
- Details on study design:
- Following intubation with C14 DADMAC, for each animal per time point, urine, feces and expired air were collected at 24, 48 and 72 hours and frozen and radioactivity was determined.
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, faeces, expired air, blood, spleen, kidney , liver, bone marrow and three section of the gastrointestinal tract.
- Time and frequency of sampling: 24, 48 and 72 hours after intubation
- Other: Carcasses, after removal of skin and feet, were homogenized and radioactivity determined.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
No change in clinical signs was observed in the treated animals. There was a slight weight loss in the study. The primary route of excretion for C14 derived from DADMAC monomer was feces.
Samples C14 radioactivity | Animal | Treatment ( hours ) | Cumulative excretion | ||
0 -24 | 24 -48 | 48 -72 | |||
Urine |
1 | 1.3% | no | no | 1.3% |
2 | 9.3 % | 0.69% | no | 9.99% | |
3 | 8.5% | 1.3% | 0.31% | 10.11% | |
Faeces |
1 | 68.1% | no | no | 68.1% |
2 | 51.7% | 9.8% | no | 61.5% | |
3 | 21.3% | 8.6% | 0.28% | 30.18% | |
Air (CO2) |
1 | 0% | no | no | 0% |
2 | 0.026% | 0.047 | no | 0.073% | |
3 | 0.016% | 0.018% | 0.012% | 0.046% |
The tissue levels for monomer were very low at each time point and there was no accumulation in any organ. The highest concentration of any organ was liver which had 0.0034% of the administered radioactivity
Animal /weight | dose (mg/kg ) |
Blood | Tissues | Gastro intestinal | Carcass | Total C14excretion |
1 / 108g | 656 | 0.004% | 0.03% | 69.43% | ||
2 / 153g | 1585 | 0.002% | 0.008% | 0.006% | 0.004% | 71.62% |
3 / 180g | 1591 | 0.001% | 0.005% | 0.006% | 0.02% | 40.37% |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
DADMAC was poorly absorbed. Of the tissues studied, the liver was found to have the largest percent uptake. The principle route of excretion was via the faeces followed by the urinary pathway with a very low amount being excreted via the expired air. The largest elimination was observed to occur during the first 24 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.