2-methoxyethyl acrylate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given. An increased application volume of 1 mL was used. Only 4 and 48 h readings were performed; the study was terminated after 48 h. No erythema or edema scores were given.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

1mL of the test substance was applied (instead of 0.5 mL); only 4 h and 48 h readings, no scores

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

other: 49 CFR 173.1200 Method of testing corrosion to skin

Deviations:

yes

Remarks:

1mL of the test substane was applied (instead of 0.5 mL)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methoxyethyl acrylate

EC Number:

221-499-3

EC Name:

2-methoxyethyl acrylate

Cas Number:

3121-61-7

Molecular formula:

C6H10O3

IUPAC Name:

2-methoxyethyl acrylate

Details on test material:

- Name of test material (as cited in study report): Sipomer MCA, 2-Propenoic acid, 2-methoxyethyl ester
- Physical state: clear liquid
- Analytical purity: 99%
- Lot No.: E169H8
- Other: pH not available

Test animals

Species:

rabbit

Strain:

other: New Zealand Albino

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Skippack, Farms, Skippack, Pa., USA
- Housing: during the study period, the rabbits were individually housed in stainless steel wire bottomed cages.
- Diet: Fisher Rabbit Pellets, ad libitium
- Water: ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.0-22.2
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied: 1 mL

Duration of treatment / exposure:

4 h

Observation period:

72 h
reading time points: 4 h and 48 h after exposure

Number of animals:

6

Details on study design:

TEST SITE
- Area of exposure: 2.5 cm2
- Type of wrap if used: the treated skin was covered with a gauze patch, held in place with adhesive tape. The entire trunk was wrapped with a rubberised elastic cloth.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 h

SCORING SYSTEM: corrosion was considered to have resulted if the test substance caused destruction or irreversible alteration of the tissue. Tissue destruction was considered to have occurred if, at any of the readings, there was ulceration or necrosis. Epidermal sloughing, erythema, edema or fissuring were not considered tissue destruction.

Results and discussion

In vivo

Results

Irritation parameter:

other: skin corrosion

Basis:

other: 5 of 6 animals

Time point:

other: 48 h

Reversibility:

other: not applicable

Remarks on result:

other: At 48 h after exposure, skin corrosion was noted in 5 of 6 rabbits.

Irritant / corrosive response data:

At the 4 h reading time point, all six rabbits showed no corrosive effects on skin. At 48 h after exposure, skin corrosion was noted in 5 of 6 rabbits. Only one animal was free of skin corrosivity.