Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature. Original report not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyc
Author:
Cosmetic Ingredient Review (CIR)
Year:
2004
Bibliographic source:
Int J Toxicol. 2004;23 Suppl 2:55-94
Reference Type:
other company data
Title:
Unnamed
Year:
1997
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Principles of method if other than guideline:
Inhalation toxicity study in rats (14 one-hour exposures during 3 weeks)
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-dihydroxypropyl laurate
EC Number:
205-526-6
EC Name:
2,3-dihydroxypropyl laurate
Cas Number:
142-18-7
Molecular formula:
C15H30O4
IUPAC Name:
2,3-dihydroxypropyl laurate
Details on test material:
- Name of test material (as cited in study report): glyceryl monolaurate
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 weeks (14 one-hour exposures)
Frequency of treatment:
1 h/day, (presumably) 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
280 mg/m³
Basis:
nominal conc.
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
NOEC
Effect level:
280 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: as reported

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

In an inhalation study in rats, glyceryl monolaurate gave a no effect level of 280 mg/m³ in 14 one-hour exposures during three weeks.

Applicant's summary and conclusion