Registration Dossier
Registration Dossier
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EC number: 205-526-6 | CAS number: 142-18-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature. Original report not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyc
- Author:
- Cosmetic Ingredient Review (CIR)
- Year:
- 2 004
- Bibliographic source:
- Int J Toxicol. 2004;23 Suppl 2:55-94
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- Inhalation toxicity study in rats (14 one-hour exposures during 3 weeks)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-dihydroxypropyl laurate
- EC Number:
- 205-526-6
- EC Name:
- 2,3-dihydroxypropyl laurate
- Cas Number:
- 142-18-7
- Molecular formula:
- C15H30O4
- IUPAC Name:
- 2,3-dihydroxypropyl dodecanoate
- Details on test material:
- - Name of test material (as cited in study report): glyceryl monolaurate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 weeks (14 one-hour exposures)
- Frequency of treatment:
- 1 h/day, (presumably) 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
280 mg/m³
Basis:
nominal conc.
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- 280 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: as reported
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
In an inhalation study in rats, glyceryl monolaurate gave a no effect level of 280 mg/m³ in 14 one-hour exposures during three weeks.
Applicant's summary and conclusion
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