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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature. Original report not available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyc
Author:
Cosmetic Ingredient Review (CIR)
Year:
2004
Bibliographic source:
Int J Toxicol. 2004;23 Suppl 2:55-94
Reference Type:
other company data
Title:
Unnamed
Year:
1997
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Principles of method if other than guideline:
Inhalation toxicity study in rats (14 one-hour exposures during 3 weeks)
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-dihydroxypropyl laurate
EC Number:
205-526-6
EC Name:
2,3-dihydroxypropyl laurate
Cas Number:
142-18-7
Molecular formula:
C15H30O4
IUPAC Name:
2,3-dihydroxypropyl dodecanoate
Details on test material:
- Name of test material (as cited in study report): glyceryl monolaurate
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 weeks (14 one-hour exposures)
Frequency of treatment:
1 h/day, (presumably) 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
280 mg/m³
Basis:
nominal conc.
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
NOEC
Effect level:
280 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: as reported

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

In an inhalation study in rats, glyceryl monolaurate gave a no effect level of 280 mg/m³ in 14 one-hour exposures during three weeks.

Applicant's summary and conclusion