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EC number: 271-729-1 | CAS number: 68606-18-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing according to OECD 211 is ongoing
Key value for chemical safety assessment
Additional information
No experimental data evaluating the chronic toxicity of Glycerides, mixed coco, decanoyl and octanoyl (CAS No. 68606-18-8) to aquatic invertebrates are available. Therefore, toxicity data from analogue category members, propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) and Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7), are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Glycerides, mixed coco, decanoyl and octanoyl is mainly a triglyceride formed by the combination of fatty acids of different C-chain lengths (C6 to C18 unsaturated) and glycerol. Propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) is also a triglyceride with fatty acid chain length of C7. For Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7) the triester content is lower than for the other two substances (up to 15%), with a predominant monoester content. The lower degree of esterification might have an effect in the bioavailability to aquatic organisms, due to a reduced size of the molecules, the potential to cross biological membranes is expected to increase. Therefore, Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- can be regarded as a worst-case read-across substance.The behaviour of these three substances in the water phase is expected to be very similar based on low water solubility values (< 0.05 mg/L for all) and log Pow (> 4). The two read-across substances cover the whole fatty acid C-chain range present in Glycerides, mixed coco, decanoyl and octanoyl. Therefore, they are considered to give a reliable indication of the toxicity of this substance to aquatic organisms, and the read-across is justified.
The chronic toxicity of Glycerides, C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7) to aquatic invertebrates has been evaluated by Salinas (2013). This test was conducted according to OECD 211, under GLP conditions. Daphnia magna was exposed to the substance at a single loading rate of 10 mg/L (limit test) for 21 days within a semi-static water regime. At the end of the exposure period, no effects on survival, reproduction or any other adverse effects were reported. Therefore the NOELR was determined to be ≥ 10 mg/L (nominal, loading rate). The chronic toxicity of propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) to aquatic invertebrates has been evaluated by Schlechtriem (2012). This test was conducted according to OECD 211, under GLP conditions. Daphnia magna was exposed to the substance at a single test concentration (100 mg/L, limit test) for 21 days within a semi-static water regime. At the end of the exposure period, no effects on mobility, timing for reproduction (1st brood) or body length were reported. On the other hand, statistically significant differences between control and treatment group were observed regarding the number of offspring (inhibition effect of 15.5%). Therefore, the overall NOELR could not be determined. Due to this fact,a new test according to OECD 211 is ongoing. The dossier will be updated as soon as possible and the Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 will be re-evaluated based on the outcome of this new study.
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