Registration Dossier
Registration Dossier
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EC number: 261-521-9 | CAS number: 58958-60-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 Jan - 12 Mar 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
- Water solubility:
- >= 1.9 - <= 27 µg/L
- Temp.:
- 19 °C
- pH:
- 6.3
- Remarks on result:
- other: pH of millipore water: 6.8
Reference
Quantitative determination of the analyte:
Flow rate (mL/h) |
Fraction No. |
Volume of combined fractions (mL) |
Solubility of test item (µg/L) |
25.0 |
1(1-2) |
27.0 |
14.1 |
2(3-4) |
27.0 |
14.8 |
|
3(5-6) |
27.0 |
27.0 |
|
4(7-8) |
27.0 |
19.3 |
|
5(9-10) |
27.0 |
24.8 |
|
6(11-12) |
27.0 |
13.7 |
|
7(13-14) |
27.0 |
15.9 |
|
8(15-16) |
27.0 |
22.2 |
|
12.5 |
1(1-2) |
26.5 |
10.2 |
2(3-4) |
27.0 |
5.2 |
|
3(5-6) |
26.5 |
5.5 |
|
4(7-8) |
27.0 |
3.0 |
|
5(9-10) |
27.0 |
4.8 |
|
6(11-12) |
27.0 |
1.9 |
|
7(13-14) |
27.0 |
2.2 |
|
8(15-16) |
27.0 |
3.3 |
Solubility of the test item ranges from 1.9 to 27.0 µg/L (mean value at 25.0 mL/h = 19.0 µg/L, mean value at 12.5 mL/h = 4.5 µg/L, overall mean value = 11.7 µg/L. Contrary to the guideline requirements, the determined concentrations differed more than 30%. It is considered acceptable due to the very low concentration of the test item.
Description of key information
1.9 to 27.0 µg/L at 19 °C and pH=6.3 (OECD Guideline 105, column elution method)
Key value for chemical safety assessment
- Water solubility:
- 11.7 µg/L
- at the temperature of:
- 19 °C
Additional information
Solubility of the test item ranges from 1.9 to 27.0 µg/L (mean value = 11.7 µg/L). Contrary to the guideline requirements, the determined concentrations differed more than 30%. The mean value is considered acceptable for the safety assessment due to the very low solubility of the test item.
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