Registration Dossier
Registration Dossier
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EC number: 233-401-6 | CAS number: 10141-00-1
Toxicity to birds
Administrative data
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Method used not generally accepted.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and teratogenicity of food additive chemicals in the developing chicken embryo.
- Author:
- Verrett, M.J., Scott, W.F., Reynaldo, E.F., Alterman, E.K., and Thomas, C.A.
- Year:
- 1 980
- Bibliographic source:
- Toxicology and Applied Pharmacology 56:265-273.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium sulfate
- EC Number:
- 231-915-5
- EC Name:
- Potassium sulfate
- Cas Number:
- 7778-80-5
- Molecular formula:
- H2O4S.2K
- Test material form:
- solid: crystalline
Constituent 1
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on preparation and analysis of diet:
- The test compound was dissolved or suspended in an appropriate vehicle and injected into the yolk and through the air cell.
Test organisms
- Test organisms (species):
- other: Single-comb White Leghorn chick eggs
Study design
- Total exposure duration (if not single dose):
- 4 d
- No. of animals per sex per dose and/or stage:
- 20 or more eggs
- Control animals:
- yes, concurrent no treatment
- Nominal and measured doses / concentrations:
- Up to 10.0 mg/egg
- Details on test conditions:
- Potassium sulfate was administered into both the yolk and through the air cell. For both injection routes, eggs were treated at 0-hours (preincubation) and at 4-days. Groups of 20 or more eggs were treated under these four conditions at a minimum of four dose levels. Percentage mortality and number of mortalities were recorded.
Examinations
- Details on examinations and observations:
- Percentage mortality and number of mortalities were recorded.
- Reference substance (positive control):
- not specified
Results and discussion
Effect levels
- Duration (if not single dose):
- 4 h
- Dose descriptor:
- LD50
- Effect level:
- > 5 - < 5.01 other: mg/egg
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Conclusions:
- LD50(96-h) = 5.01 mg/egg
Potassium sulfate showed no teratogenic response under any of the four conditions.
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