Registration Dossier
Registration Dossier
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EC number: 221-499-3 | CAS number: 3121-61-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (72h) > 100 mg/L (nominal) (activated sludge, ASTM method: Microbiological Inhibition Testing Procedure, BOD), RA
Key value for chemical safety assessment
Additional information
Since no data on the short-term toxicity of 2-methoxyethyl acrylate (CAS 3121-61-7) to microorganisms are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 read-across to another structurally related analogue substance was conducted. Read-across data from ethyl acrylate (CAS 140 -88 -5) were used, which was considered suitable for read-across.
The key study was conducted with ethyl acrylate according to GLP and a test method based on ASTM's "Microbiological Inhibition Testing Procedure" which is a modification of the standard five day biochemical oxygen demand (BOD) analysis. Domestic activated sludge was used as inoculum. Within this study, nominal test concentrations of 0.1, 1.0, 5.0, 10, 15, 20, 100, 300, 500 and 800 mg/L were applied. Analytical measurements achieved by TOC determination showed a difference between theoretical and measured TOC of 5 %. As a result, a 72h-EC10 value of > 100 mg/L for respiration rate was determined based on nominal concentrations (Roy F. Weston, 1996).
Due to structural and property similarities with the tested analogue substance, it can be concluded that the above result also applies to 2-methoxyethyl acrylate (CAS 3121-61-7). For details see analogue justification in the overall summary of Chap 6.1 and in Chapter 13 of the Technical Dossier.
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