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EC number: 203-996-7 | CAS number: 112-67-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound palmitoyl chloride: No data.
Hydrolysis product palmitic acid: With high probability acutely not harmful to aquatic invertebrates within range of water solubility.
Hydrolysis product HCl: Acutely very toxic for aquatic invertebrates (pH dependent).
Key value for chemical safety assessment
Additional information
Parent compound palmitoyl chloride (CAS 112 -67 -4):
No data are available for palmitoyl chloride (CAS 112 -67 -4). The substance rapidly decomposes in water (t1/2 < 5 min) and forms HCl (CAS 7647 -01 -0) and palmitic acid (CAS 57 -10 -3). Therefore, the short-term toxicity to aquatic invertebrates is assessed on the basis of data on palmitic acid.
Hydrolysis product palmitic acid (CAS 57 -10 -3):
For palmitic acid (CAS 57 -10 -3) two limit tests are available to assess the short-term toxicity towards aquatic invertebrates.
- The immobilization of D. magna was investigated according to OECD TG 202 (OECD, 2004) and under GLP. The exposure was semistatic. The test solutions were prepared using a vehicle. The test concentrations were analytically verified. The 48-h EC50 was determined to be > 0.25 mg/L (based on time weighted mean measured concentrations, NITE, 2006).
- In a static acute immobilization test according to OECD TG 202 (OECD, 1984), the 48-h EC50 was determined to be > 4.8 mg/L (measured geomean concentrations, NITE, 2000). The test solutions wre prepared using a vehicle.
The effect values determined in both studies are clearly above the water solubility for palmitic acid (WS = 0.04 mg/L, at 25 °C, Robb 1966, PhysProp database of EPI Suite v4.11).
In conclusion, with high probability palmitic acid is acutely not harmful to aquatic invertebrates within range of water solubility.
Hydrolysis producthydrochloric acid (HCl; CAS 7647 -01 -0):
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 with Daphnia magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; OECD SIDS, 2002).
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