Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Disodium octaborate
  • IUPAC name: disodium bis[(oxoboranyl)oxy]bicyclo[5.5.1]hexaboroxane-3,5-bis(olate)
  • Other names
EC / List no.:
234-541-0
CAS no.:
12008-41-2
Index number:
005-020-00-3
Molecular formula:
B8Na2O13
SMILES:
[Na+].[Na+].[O-]B1OB([O-])OB2OB(OB=O)OB(OB=O)OB(O1)O2
InChI:
InChI=1S/B8O13.2Na/c9-1-13-5-18-6(14-2-10)20-8-17-4(12)15-3(11)16-7(19-5)21-8;;/q-2;2*+1
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP09) approved by the European Union, this substance may damage fertility and may damage the unborn child.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation.

Breakdown of all 187 C&L notifications submitted to ECHA

Repr. 1B H360FD Harmonised Classification
Repr. 1A H360
Eye Irrit. 2 H319
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 7 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 3 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: wood preservation.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), wood (e.g. floors, furniture, toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: fertilisers, biocides (e.g. disinfectants, pest control products), coating products, inks and toners and metal surface treatment products.

This substance is used in the following areas: building & construction work, agriculture, forestry and fishing, offshore mining and printing and recorded media reproduction. This substance is used for the manufacture of: machinery and vehicles and fabricated metal products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, non-industrial spraying, treatment of articles by dipping and pouring, closed, continuous processes with occasional controlled exposure, the low energy manipulation of substances bound in materials or articles, batch processing in synthesis or formulation with opportunity for exposure and roller or brushing applications.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: biocides (e.g. disinfectants, pest control products), coating products, fertilisers, inks and toners, adhesives and sealants, pH regulators and water treatment products and welding & soldering products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, mixing in open batch processes, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and in the production of articles.

This substance is used in the following products: biocides (e.g. disinfectants, pest control products), coating products, inks and toners, adhesives and sealants and metal surface treatment products.

This substance is used in the following areas: offshore mining, building & construction work, printing and recorded media reproduction and agriculture, forestry and fishing. This substance is used for the manufacture of: machinery and vehicles, mineral products (e.g. plasters, cement), wood and wood products, pulp, paper and paper products, fabricated metal products, electrical, electronic and optical equipment and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Aries S.p.A., Via Egadi, 5 20144 Milano Italy
  • Balchem Italia srl, Via del Porto snc 28040 Marano Ticino NO Italy
  • Borax Europe Limited, 6 St. James's Square SW1Y 4AD London United Kingdom
  • ETIMINE SA, 204, Zone Industrielle Scheleck 2 L-3225 Bettembourg Luxembourg Luxembourg
  • Rio Tinto Iron & Titanium GmbH (5), Mergenthalerallee 77 65760 Eschborn Hesse Germany
  • SCL ITALIA S.P.A., Via Fabio Filzi 25/A 20124 Milan Italy

Other names

  • -
  • disodium bis[(oxoboranyl)oxy]bicyclo[5.5.1]hexaboroxane-3,5-bis(olate)
  • Disodium Octaborate
  • disodium octaborate tetrahydrate
  • Octoborato de Sodio
  • Disodium octaborate
  • disodium octaborate anhydrous
  • Disodium octaborate tetrahydrate
  • Borasol
  • disodium octaborate
  • Disodium Octaborate Tetrahydrate
  • DOT
  • Etidot-67
  • Missibor
  • Mycrobor®
  • Octabor
  • Polybor
  • Solubor
  • Superflor
  • Tim-bor
  • Yara Vita

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Crystalline (100%) [2]
C Odour
Odourless (100%) [2]
C Substance type
Inorganic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 2 studies processed
R Melting / freezing point
1 000 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 2 studies submitted
  • 2 studies processed
R Density
1.874 g/cm³ @ 22 °C [2]
R Relative density
1.87 @ 22 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 2 studies submitted
  • 2 studies processed
R Vapour pressure
0 Pa @ 25 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
223.65 g/L @ 20 °C and pH 7.6 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
223.65 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
8.94 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
8.94

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.9 mg/L (2)
Intermittent releases (freshwater) 13.7 mg/L (2)
Marine water 2.9 mg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (2)
Sediment (freshwater) No exposure of sediment expected (2)
Sediment (marine water) No exposure of sediment expected (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 5.7 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 28 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 74 - 79.7 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 24
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
79.7 mg/L
LC50 for marine water fish
74 mg/L

Long–term toxicity to fish

Study results
  • 32 studies submitted
  • 22 studies processed
P/RResults
NOEC (34 days) 6.4 mg/L [6]
NOEC (32 days) 11.2 - 44.5 mg/L [4]
LOEC (32 days) 23 mg/L [2]
EC10 (34 days) 6.9 - 18 mg/L [4]
LC10 (34 days) 18.3 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 22
Other 10
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 68 studies submitted
  • 46 studies processed
P/RResults
LC50 (4 days) 64 - 544 mg/L [30]
LC50 (48 h) 91 - 165 mg/L [16]
NOEC (4 days) 103 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 46
Other 22
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 24 studies submitted
  • 20 studies processed
P/RResults
NOEC (42 days) 6.6 - 25.9 mg/L [6]
NOEC (28 days) 16.6 - 43.3 mg/L [24]
NOEC (21 days) 6 - 34.2 mg/L [18]
NOEC (14 days) 13.8 - 14.3 mg/L [12]
NOEC (12 days) 33.1 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 20
Other 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 50 studies submitted
  • 4 studies processed
P/RResults
EC50 (72 h) 40.2 - 66 mg/L [8]
NOEC (72 h) 17.5 - 27.9 mg/L [6]
LOEC (62.4 h) 70.1 mg/L [2]
EC10 (72 h) 24.5 - 50.7 mg/L [8]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 46
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (10 days) 6.5 mg/L [2]
LOEC (10 days) 3.6 - 19.5 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 4
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 18 studies submitted
  • 16 studies processed
P/RResults
EC50 (3 h) 175 - 10 000 mg/L [4]
NOEC (72 h) 10 - 20 mg/L [8]
NOEC (7 h) 100 mg/L [2]
NOEC (3 h) 17.5 - 20 mg/L [4]
LOEC (72 h) 20 - 25 mg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 18
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
10 mg/L

Sediment toxicity

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
NOEC (28 days) 37.7 - 201.6 mg/kg sediment dw [18]
NOEC (28 days) 20 - 43 mg/L [10]
NOEC (21 days) 80.6 - 284 mg/kg sediment dw [4]
LOEC (28 days) 37.7 mg/kg sediment dw [2]
LOEC (28 days) 40 - 43 mg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 18 studies submitted
  • 18 studies processed
P/RResults
NOEC (63 days) 19.8 - 78.8 mg/kg soil dw [16]
NOEC (56 days) 5.2 - 98 mg/kg soil dw [20]
NOEC (28 days) 174.8 - 315 mg/kg soil dw [8]
NOEC (14 days) 175 mg/kg soil dw [4]
EC10 (56 days) 70.1 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 18
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
NOEC (35 days) 21.9 - 175 mg/kg bw [12]
NOEC (21 days) 174.8 mg/kg soil dw [2]
NOEC (16 days) 98.2 mg/kg soil dw [2]
EC10 (28 days) 13.8 - 68.1 mg/kg bw [8]
EC10 (21 days) 47.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 46 studies submitted
  • 4 studies processed
P/RResults
NOEC (60 days) 5 mg/kg soil dw [2]
NOEC (21 days) 5.25 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 42
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
NOEC (28 days) 419.6 mg/kg soil dw [2]
EC10 (3.4 months) 15.4 - 17.2 mg/kg soil dw [4]
EC10 (28 days) 3 - 226 mg/kg soil dw [12]
EC50 (3.4 months) 17.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.9 mg/m³ developmental toxicity / teratogenicity
Acute /short term: - -
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 326 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.5 mg/m³ irritation (respiratory tract)
Acute /short term: - -
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 163.3 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 810 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 810 µg/kg bw/day developmental toxicity / teratogenicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 26 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.5 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 30 studies submitted
  • 8 studies processed
P/RResults
LD50 2 500 - 4 080 mg/kg bw (rat) [8]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 8
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 12 studies submitted
  • 8 studies processed
P/RResults
LC50 (5 h) 2.03 mg/L air (rat) [2]
LC50 (4 h) 2.01 - 2.12 mg/L air (rat) [6]
M/CInterpretations of results
Other [8]

inhalation
Studies with data
Key study 8
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 8 studies submitted
  • 6 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [6]
M/CInterpretations of results
Practically nontoxic [4]

dermal
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 550 mg/kg bw
Inhalation route:
No adverse effect observed LC50 2 010 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study 10
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: eye
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 8
Supporting study 12
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 42 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 17.5 - 100 mg/kg bw/day [4]
LOAEL (rat): 58.5 - 334 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 40
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 83.3 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 40 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study 34
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed NOAEL 957 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 6
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 26 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 6
Supporting study 20
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant