Calcium sulfate

This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered from most to least commonly provided, with the percentage of provided values appended. The percentage is based on the count of values provided.

Physical state

For substance’s physical state at 20°C and 1 013 hPa, registrants can classify their substance as:

• Solid
• Liquid
• Gaseous

Form

For substance’s form, registrants can classify their substance as:

• Aerosol dispenser: not specified
• Aerosol dispenser: foam aerosol
• Aerosol dispenser: spray aerosol
• Gas
• Gas: vapour
• Gas under pressure: compressed gas
• Gas under pressure: dissolved gas
• Gas under pressure: liquefied gas
• Gas under pressure: refrigerated liquefied gas
• Liquid
• Liquid: viscous
• Liquid: volatile
• Liquid – liquid: emulsion
• Liquid – solid: mixture of
• Semi–solid (amorphous): gel
• Solid
• Solid: bulk
• Solid: compact
• Solid: crystalline
• Solid: fibres
• Solid: filaments
• Solid: flakes
• Solid: granular
• Solid: pellets
• Solid: particulate/powder
• Solid: nanomaterial, surface–treated
• Solid: nanomaterial, no surface treatment
• Solid: nanomaterial
• Solid – liquid: aqueous solution
• Solid – liquid: suspension
• Solid – solid: alloy
• Aerosol
• Compact
• Crystalline
• Dispersion
• Fibre
• Filaments
• Flakes
• Liquefied gas
• Nanomaterial
• Particulates
• Paste
• Pellets
• Powder
• Refrigerated liquid
• Suspension
• Viscous
• Other
• No data

Odour

For substance’s odour, registrants can classify their substance as: 

• Ammonia-like
• Biting
• Characteristic of sulphur containing compounds
• Characteristic of aromatic compounds
• Faint
• Garlic-like
• Odourless
• Pungent
• Slight
• Sweetish
• Other

Type

For substance’s type, registrants can classify their substance as:

• Element
• Inorganic
• Natural substance
• Organic
• Organometallic
• Petroleum product
• Other

Summary

Summary data is collected from the endpoint summary(ies) provided by registrants of REACH dossiers.

Physical state at 20°C and 1013 hPa

For substance’s physical state at 20°C and 1013 hPa, registrants can classify their substance as:

• Solid
• Liquid
• Gaseous

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications.

This section summarises the melting and freezing point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa.

Results without measurement conditions (pressure) are not processed for the Brief Profile. Additionally, if registrants select ‘other’ as a unit of measure for pressure, the measurement conditions (and therefore the study results) cannot be processed in the Brief Profile.

Summary

Melting/freezing point at 101 325 Pa provides information on the substance melting/freezing point in °C at a pressure of 101 325 Pa.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data–waving justifications.

This section summarises the boiling point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header .

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).
Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C).

Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. 

Density provides substance information on the density in grams per (centi)metre at a temperature measured in °C. 

Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C. 

Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C. 

Note: Registrants can also select ‘other’ as the type of density. If so, the data provided is not processed for the Brief Profile.

Summary

Relative density at 20 °C provides information on the substance relative density at 20 °C. If more than one value is found for this section, the range of min-max values will be displayed here.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data-waving justifications.

This section summarises the density values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).
Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C).

Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. 

Density provides substance information on the density in grams per (centi)metre at a temperature measured in °C. 

Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C. 

Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C. 

Note: Registrants can also select ‘other’ as the type of density. If so, the data provided is not processed for the Brief Profile.

Summary

Relative density at 20 °C provides information on the substance relative density at 20 °C. If more than one value is found for this section, the range of min-max values will be displayed here.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the vapour pressure values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C.

Note: Registrants can also select ‘other’ as the unit of measure for pressure. If so, the pressure data provided is not processed for the Brief Profile.

Summary

Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and data waving justifications.

This section summarises the partition coefficient values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH.

Log Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH.

Summary

Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications

This section summarises the water solubility values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Values provided in ppb and Vol% are provided separately.

Summary

Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the surface tension values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C.

Note: Results without a concentration value are not processed for the Brief Profile.

Also, if the registrant selects ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure for the concentration value, the data provided will not be processed for the Brief Profile.

Summary

Surface tension at 20°C provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre, at a temperature of 20 °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the flash point values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max, RANGE method) will be presented.

Flash point provides substance information on the substance’s flash point at a temperature measured in °C at a pressure  measured in Pascal.

Summary

Flash point at 101 325 Pa provides substance information on the substance’s flash point at a temperature measured in °C at a pressure of 101 325 Pascal.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the auto flammability values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Autoflammability / Self-ignition provides substance information on the substance’s self-ignition temperature in °C  at a pressure measured in Pascal.

Note: Registrants can also select ‘other’ as the unit of measure for pressure. If so, the pressure data provided is not processed for the Brief Profile.

Summary

Autoflammability / Self-ignition at 101 325 Pa provides substance information on the substance’s self-ignition temperature in °C at a pressure of 101 325 Pa.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the flammability values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Applicant’s summary and conclusion – Interpretation of results. Registrants can register their substance flammability as:

• Extremely flammable aerosols (Cat. 1)
• Flammable gases (Cat.1)
• Flammable solids (Cat.1)
• Pyrophoric liquids (Cat.1)
• Pyrophoric solids (Cat. 1)
• Self-heating substances and mixtures (Cat. 1)
• Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.1)
• Flammable aerosols (Cat.2)
• Flammable gases (Cat.2)
• Flammable solids (Cat.2)
• Self-heating substances and mixtures (Cat.2)
• Substances or mixtures which in contact with water release flammable gases which may ignite spontaneously (Cat.2)
• Non-flammable aerosols (Cat.3)
• Substances or mixtures which in contact with water releases flammable gases (Cat.3)
• Chemically unstable gases (Cat.A)
• Chemically unstable gases (Cat.B)
• GHS criteria not met
• Not classified based on GHS criteria
• Extremely flammable
• Extremely flammable liquefied gas
• Substances and mixtures which in contact with water emit flammable gases
• Contact with water liberates highly flammable gases
• Highly flammable
• Flammable
• Pyrophoric
• Spontaneously flammable in air (pyrophoric)
• Non–flammable
• Non flammable (based on GHS criteria)
• No information available
• Not classified

Note: Registrants can also select ‘other’ as the flammability value for their substance. If so, the data provided is not processed for the Brief Profile.

Summary

Registrants can register their substance’s flammability as:

• Extremely flammable
• Extremely flammable liquefied gas
• Contact with water liberates highly flammable gases
• Highly flammable
• Flammable
• Spontaneously flammable in air (pyrophoric)
• Non–flammable

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the explosiveness values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Applicant’s summary and conclusion – Interpretation of results. Registrants can register their substance explosiveness as:

• Unstable explosive
• Mass explosion hazard (Div. 1.1)
• Projection hazard but not a mass explosion hazard (Div. 1.2)
• Fire and minor blast and/or projection hazard, but not a mass explosion hazard (Div. 1.3)
• No significant hazard (Div. 1.4)
• Very insensitive substances with mass explosion hazard (Div. 1.5)
• Extremely insensitive which do not have a mass explosion hazard (Div. 1.6)
• GHS criteria not met
• Explosive
• Non explosive

Summary

Explosiveness. Registrants can register their substance explosiveness as:

• Explosive
• Non explosive

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the oxidising values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Applicant’s summary and conclusion – Interpretation of results. Registrants can register their substance’s oxidising properties as:

• no oxidising properties
• oxidising: maximum burning rate equal or higher than reference mixture
• oxidising: vigorous reaction in preliminary test
• oxidising;
• test not applicable because organic peroxide.

Note: Registrants can also select ‘other’ as the oxidising value for their substance. If so, the data provided is not processed for the Brief Profile.

Summary

Oxidising. Registrants can register their substance oxidising properties as:

• Oxidising
• Yes
• Non oxidising
• No
• No information available

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the dissociating values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissociating Properties provides substance information by picklist values:

• Yes
• No
• Ambiguous
• Not determined

Dissociation Constant provides numerical substance information on the substance’s dissociation constant values at a temperature measured in °C.

Summary

pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the viscosity values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method).

Registrants can report substance information on viscosity as:

• Dynamic viscosity (in mPa s)
• Kinematic viscosity (in mm²)/s)
• Flow time (in s) – ASTM Cup 1
• Flow time (in s) – ASTM Cup 2
• Flow time (in s) – ASTM Cup 3
• Flow time (in s) – ASTM Cup 4
• Flow time (in s) – 3 mm ISO cup
• Flow time (in s) – 4 mm ISO cup
• Flow time (in s) – 5 mm ISO cup
• Flow time (in s) – 6 mm ISO cup
• Flow time (in s) – other:

Summary

Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C.

Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to hydrolysis from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary

Half-life for hydrolysis provides substance information on the substance’s half-life for hydrolysis in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.
Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. 

COD provides substance information on the substance’s COD values displayed in O2 (milli)gram per gram test material. 

BOD5*100/COD provides substance information on the substance’s BOD5*100/COD values displayed in O2 (milli)gram per gram test material. 

BOD5/COD ratio provides substance information on the substance’s BOD5/COD ratio values displayed in O2 (milli)gram per gram test material. 

BOD5/ThOD ratio provides substance information on the substance’s BOD5/ThOD ratio values displayed in O2 (milli)gram per gram test material. 

BOD5*100/ThOD provides substance information on the substance’s BOD5*100/ThOD values displayed in O2 (milli)gram per gram test material. 

ThOD provides substance information on the substance’s ThOD values displayed in O2 (milli)gram per gram test material. 

Note: Registrants can also select ‘other’ as the unit of measure. If so, the data provided is not processed for the Brief Profile.

Applicant’s summary and conclusion – Interpretation of results provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options:

• Readily biodegradable
• Readily biodegradable but failing the 10-day window
• Inherently biodegradable
• Inherently biodegradable, fulfilling specific criteria;
• Inherently biodegradable, not fulfilling specific criteria
• Not inherently biodegradable
• Not readily biodegradable
• Under test conditions no biodegradation observed

Note: Registrants can also select ‘other’ as picklist option for describing the biodegradation values of the substance in water. If so, the data provided is not processed in the Brief Profile.

Summary

Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options:

• Readily biodegradable
• Readily biodegradable but failing the 10-day window
• Inherently biodegradable
• Inherently biodegradable, fulfilling specific criteria;
• Inherently biodegradable, not fulfilling specific criteria
• Under test conditions no biodegradation observed

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in water provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles.

Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.
Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to biodegradation in soil from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Bioaccumulation factor (aquatic species) provides substance information on the substance’s bioaccumulative properties not taking account the dimensions.

Bioaccumulation Factor (aquatic species) L/kg ww provides substance information on the substance’s bioaccumulative properties for aquatic species measured in litre per kilogram  (wet weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Bioaccumulation factor (terrestrial species) provides substance information on the substance’s terrestrial bioaccumulative properties not taking account the dimensions.

Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to adsorption/desorption from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Log Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Log Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Note: If the measurement condition (percentage of organic carbon) is not provided by the registrant for adsorption coefficient Kd, the data provided is not processed for the Brief Profile.

Summary

Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C.

Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method).

Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms.

Manufacturers and importers can provide the following information in the registration dossier:

Freshwater/marine water/intermittent:

• PNEC aqua, displayed in milligram per litre.
• No data: aquatic toxicity unlikely
• No data available: testing technically not feasible
• No hazard identified

Sewage treatment plant (STP)

• PNEC STP, data displayed in milligram per litre.
• No data: aquatic toxicity unlikely
• No data available: testing technically not feasible
• No emission the STP expected
• No hazard identified

Sediment freshwater/marine water

• PNEC sediment, data displayed in milligram per kilo sediment (dry weight).
• No or insufficient data available at present
• No exposure of sediment expected
• No data available: testing technically not feasible
• No hazard identified

Hazard for Air provides information on the substance’s hazard assessment conclusion related to air.

Data is generally standardised and displayed in milligram per litre/cubic metre.

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC air
• Hazard related to composition of atmosphere identified
• No hazard identified 

Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil.

Data is generally standardised and displayed in milligram per kilo soil (dry weight).

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC soil
• No or insufficient data available at present
• No exposure of soil expected
• No data available: testing technically not feasible
• No hazard identified

Hazard for predators provides information on the substance’s hazard assessment conclusion related to predators/secondary poisoning.

Data is generally standardised and displayed in in milligram per kilo of food.

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC oral
• No potential for bioaccumulation
• No potential to cause toxic effects if accumulated (in higher organisms) via the food chain
• No or insufficient data available at present
• No data available: testing technically not feasible

This section summarises the values related to short–term toxicity to fish from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The five highest priority groupings of provided data are displayed in milligram per litre or molar per litre.

Prioritisation by dose descriptor:

1.  LC50
2.  LC0
3.  LC100
4.  LC10
5.  EC50
6.  EC0
7.  EC100
8.  EC10
9.  NOEC
10.  LOEC
11.  LL50
12.  LL0
13.  LL100
14.  LL10
15.  EL50
16.  EL0
17.  EL100
18.  EL10
19.  IC50
20.  IC10
21.  IC100
22.  NOELR
23.  LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater fish provides substance information on the substance’s lethal concentration for 50% of the freshwater fish in the test, displayed in milligram per litre.

LC50 for marine water fish provides substance information on the substance’s lethal concentration for 50% of the marine water fish in the test, displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. IC10
6. EC50
7. LC50
8. IC50
9. EL10
10. EL50
11. LL10
12. LL50
13. NOELR
14. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.  

EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. EC50
2. IC50
3. LC50
4. EC0
5. LC0
6. EC100
7. LC100
8. LC10
9. EC10
10. NOEC
11. LOEC
12. LL50
13. LL0
14. LL100
15. LL10
16. EL50
17. EL0
18. EL100
19. EL10
20. IC10
21. IC100
22. NOELR
23. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre.

LC50 for marine water invertebrates provides substance information on the substance’s lethal concentration for 50% of the marine water invertebrates in the test, displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance.  

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. IC10
6. EC50
7. LC50
8. IC50
9. EL10
10. EL50
11. LL10
12. LL50
13. NOELR
14. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. 

EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to aquatic algae and cyanobacteria from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1.  EC50
2.  IC50
3.  NOEC
4.  LOEC
5.  EC10
6.  IC10
7.  EC20
8.  EC5
9.  EC0
10.  EC100
11.  IC100
12.  EC90
13.  EL0
14.  EL5
15.  EL10
16.  EL20
17.  EL50
18.  EL90
19.  EL100
20.  NOELR
21.  LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre.

LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for freshwater algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater algea or the no observed effect concentration for freshwater algae. Values are generally displayed in milligram per litre. 

EC10 / LC10 or NOEC for marine water algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water algae or the no observed effect concentration for marine water algae. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. EC50
2. IC50
3. NOEC
4. LOEC
5. EC10
6. IC10
7. EC0
8. IC0
9. EC100
10. IC100

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre.

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).  

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. Values are generally displayed in milligrams per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Prioritisation by units (dry weight):

1. Mg/cm2
2. g/ha

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).  

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. . Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by unit.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Prioritisation by unit:

1. soil dw (g/ha and mg/cm²)
2. soil ww; (g/ha and mg/cm²)
3. µg per animal
4. mL/ha; mg/kg bw
5. mg/kg diet
6. ppm
7. mg/kg dung dw

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. 

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).
The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. EC50
6. LC50
7. EC0
8. EC25
9. EC100
10. LC0
11. LC25
12. LC100
13. ER0
14. ER10
15. ER25
16. ER50
17. ER100

Prioritisation by units:

1. soil dw (g/ha, kg/ha and lbs/acre).
2. soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to soil microorganisms from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. EC10
3. EC25
4. EC50
5. EC100
6. EC0
7. ER0
8. ER10
9. ER25
10. ER50
11. ER100

Prioritisation by units:

1. Soil dw (g/ha, kg/ha and lbs/acre).
2. Soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to birds from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram, per bodyweight per day. Otherwise data is displayed reported as provided by the registrant(s).
The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units .

Prioritisation by dose descriptor type:

1. NOEC
2. LOEC
3. LC50
4. LD50
5. LOEC
6. LOEL

Prioritisation by unit:

1. bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day)
2. mg/kg bw
3. mg/kg diet
4. mg/L drinking water.

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food.

Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. Values are generally displayed in milligram per kilo food.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance.

When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

When more than one result is available per endpoint the ‘worst case’ or most conservative of all the data values provided are displayed, applying a precautionary principal. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance.

Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure.

Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions:

1. DNEL (Derived No-Effect Level)
2. DMEL (Derived Minimum Effect Level) - not included for short–term effects
3. Other toxicological threshold
4. High hazard (no threshold derived)
5. Medium hazard (no threshold derived)
6. Low hazard (no threshold derived)
7. Insufficient data available (further information necessary)
8. Hazard unknown (no further information necessary)
9. No hazard identified
10. Hazard unknown but no further hazard information necessary as no exposure expected

Prioritisation of display occurs based on the order above. If a threshold is derived, the type of hazard assessment conclusion is displayed and the registered threshold is reported in (nano/micro/milli)gram per cubic metre. If more than one DNEL/DMEL is available the most conservative (i.e. the lowest numerical data) is displayed.

Information on the most sensitive study can be provided by the registrants as:

1. Acute toxicity
2. Repeated dose toxicity
3. Effect on fertility
4. Developmental toxicity/teratogenicity
5. Neurotoxicity
6. Immunotoxicity
7. Sensitisation (skin)
8. Sensitisation (respiratory tract)
9. Carcinogenicity
10. Skin irritation/corrosion
11. Irritation (respiratory tract)
12. Genetic toxicity

Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers).

See ‘Data for workers – Inhalation exposure’, with the following additional hazard assessment conclusion in the case of short term:

• ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added

The registered threshold is generally displayed in milligrams per kilogram per bodyweight per day.

Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers).

Registrant can provide information on eye exposure by selecting one of the following hazard assessment conclusions:

1. High hazard (no threshold derived)
2. Medium hazard (no threshold derived)
3. Low hazard (no threshold derived)
4. Hazard unknown (no further information necessary)
5. No hazard identified
6. Hazard unknown but no further hazard information necessary as no exposure expected

Data for general population – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for the general population).

Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’

This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study result data.

Summary

Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below.

Registrants can register their substance’s bioaccumulation properties as:

1. High bioaccumulation potential
2. Low bioaccumulation potential
3. No bioaccumulation potential

Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages.  If multiple values are available, the most conservative value (the highest percentage) is displayed.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section displays the values related to acute toxicity from all registered dossiers for the substance.

Study results - oral

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight. The availability of additional data beyond the five results displayed is indicated by (…).

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Prioritisation by dose descriptor type:

1. LD50
2. LD50 cut-off
3. Discriminating dose
4. LD0
5. LD100
6. LDLo
7. Approximate LD50

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Applicant’s summary and conclusion – Interpretation of results (oral). Registrants can choose from the following (picklist) conclusions:

1. Category 1 based on GHS criteria
2. Category 2 based on GHS criteria
3. Category 3 based on GHS criteria
4. Category 4 based on GHS criteria
5. Category 5 based on GHS criteria
6. Study cannot be used for classification
7. GHS criteria not met
8. Extremely toxic
9. Very toxic
10. Highly toxic
11. Toxic
12. Moderately toxic
13. Slightly toxic
14. Toxicity category I
15. Toxicity category II
16. Toxicity category III
17. Toxicity category IV
18. Toxicity category V
19. Practically nontoxic
20. Harmful
21. Relatively harmless
22. Not classified
23. Other

Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above.

Note: Registrants can also select ‘other’ as the picklist conclusion. If so, the data provided is not processed for the Brief Profile.

Study results - dermal

Results

See information under ‘Study results oral’.

Applicant’s summary and conclusion – Interpretation of results (dermal). See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’.

Study results - Inhalation

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight.  The availability of additional data beyond the five results displayed is indicated by (…).

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Prioritisation by dose descriptor type:

1. LC50
2. LC50 cut-off
3. Discriminating conc. 
4. LC0 
5. LC1 
6. LC100 
7. LCLo

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Applicant’s summary and conclusion – Interpretation of results (inhalation). See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’.

Study results - other routes

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligram per kilo bodyweight.  The availability of additional data beyond the five results displayed is indicated by (…) icon.

Results

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Prioritization by the dose descriptor type:

1. EC50
2. LC50
3. LD50
4. EC0
5. LC0
6. LD0
7. EC100
8. LC100
9. LD100
10. LCLo
11. LDLo

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above, i.e. the minimum numerical value associated with the highest priority picklist item.

Oral route provides substance information on the substance’s acute toxicity via the oral route. Registrants can choose from the following picklist endpoint conclusions:

1. Adverse effect observed
2. No adverse effect observed
3. No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating dose, displayed here in milligrams per kilogram bodyweight.

Dermal route provides substance information on the substance’s acute toxicity via the dermal route. Registrants can choose from the following picklist endpoint conclusions:

1. Adverse effect observed
2. No adverse effect observed
3. No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating dose, displayed here in milligrams per kilogram bodyweight.

Inhalation route provides substance information on the substance’s acute toxicity via the inhalation route. Registrants can choose from the following picklist endpoint conclusions:

1. Adverse effect observed
2. No adverse effect observed
3. No study available

If an adverse effect is observed, data can be provided as LD 50 or discriminating concentration, displayed here in milligram per cubic metre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.