Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-550-1
CAS no.:
108-10-1
Index number:
Molecular formula:
C6H12O
SMILES:
CC(C)CC(C)=O
InChI:
InChI=1S/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
20
Of which contain:
2 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a highly flammable liquid and vapour, causes serious eye irritation, is harmful if inhaled and may cause respiratory irritation.

Breakdown of all 4306 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Acute Tox. 3 H331
STOT SE 3 H370
Acute Tox. 4 H302
Asp. Tox. 1 H304
Acute Tox. 4 H312
STOT SE 3 H336
Not Classified
STOT RE 1 H372
Aquatic Chronic 2 H411
Eye Irrit. 2A H319
Carc. 2 H351
https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 31 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: coating products, biocides (e.g. disinfectants, pest control products), fillers, putties, plasters, modelling clay, anti-freeze products, lubricants and greases, finger paints and washing & cleaning products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: coating products and fillers, putties, plasters, modelling clay.

This substance is used in the following areas: health services and scientific research and development. This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, roller or brushing applications, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, non-industrial spraying and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: coating products and fillers, putties, plasters, modelling clay.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, formulation of mixtures, formulation in materials, manufacturing of the substance, as processing aid and in the production of articles.

This substance is used in the following products: coating products, lubricants and greases and fillers, putties, plasters, modelling clay.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, treatment of articles by dipping and pouring, transfer of substance into small containers, roller or brushing applications and industrial spraying.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, formulation in materials, of substances in closed systems with minimal release, as processing aid and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • Boeing Distribution, Inc. (d/b/a Aviall), Schillingweg 40 2153PL Nieuw-Vennep Noord-Holland Netherlands
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • COVANCE CLINICAL DEVELOPMENT SA 087, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • DOW BENELUX B.V. - OR2, Postbus 48 4530 AA Terneuzen Netherlands
  • Dow Silicones Belgium SPRL OR-1, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • DUSLO, Administrativna budova ev.č 1236 927 03 Šaľa Slovakia
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • GSI EUROPE-IMPORT+EXPORT GmbH, Louise-Dumont-Str, 31 40211 Duesseldorf Germany
  • Hungary Musashi Paint Kft., Bokodi u. 11 2840 Oroszlany Hungary
  • KIST Europe Forschungsgesellschaft mbH, Campus E 71 Saarbruecken 66123 Germany
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • LORD Germany GMBH, Ottostrasse 28 41836 Hueckelhoven North Rhine - Westphalia Germany
  • NP Automotive Coating (Europe) Ltd, Britannia Park Radway Road SN3 4ND Swindon Wiltshire United Kingdom
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR12, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • PPG Kansai Automotive Finishes France SAS, Les Dix Muids 59583 Marly France
  • RHODIA OPERATIONS - 1, 40 rue de la Haie Coq 93306 Aubervilliers France
  • Sasol Chemie GmbH & Co. KG, Anckelmannsplatz 1 20537 Hamburg Germany
  • Shell Nederland Raffinaderij B.V., Vondelingenweg 601 Postbus 3000 3196 KK Rotterdam Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Specialty Electronic Materials Netherlands BV OR-3, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands

Substance names and other identifiers

4-methylpentan-2-one
EC Inventory, C&L Inventory, REACH pre-registration, EU. Indicative OELVs - Directive 2000/39/EC, EU. Dangerous Substances - Eco-Labels
4-methylpentan-2-one; isobutyl methyl ketone
EU. Worker Protection-Hazardous (98/24), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
isobutyl methyl ketone
C&L Inventory, EU. Dangerous Substances - Eco-Labels
METHYL ISOBUTYL KETONE
Other, EU. ADN Dangerous Goods Lists, Directive 2008/68/EC, EU. ADR Dangerous Goods Lists, Directive 2008/68/EC, EU. RID Dangerous Goods Lists, Directive 2008/68/EC, EU. Regenerated Cellulose Film Substances
4-methylpentaan-2-on (nl)
C&L Inventory
4-methylpentan-2-on (cs)
C&L Inventory
4-metil, 2-pentanona (ro)
C&L Inventory
4-metil-pentan-2-on (hr)
C&L Inventory
4-metil-pentan-2-one (it)
C&L Inventory
4-metilpentan-2-on (sl)
C&L Inventory
4-metilpentan-2-ona (es)
C&L Inventory
4-metilpentan-2-onas (lt)
C&L Inventory
4-metilpentano-2-ona (pt)
C&L Inventory
4-metilpentanons-2 (lv)
C&L Inventory
4-metilpentán-2-on (hu)
C&L Inventory
4-metylopentan-2-on (pl)
C&L Inventory
4-metylpentan-2-on (no)
C&L Inventory
4-metylpentán-2-ón (sk)
C&L Inventory
4-metyylipentan-2-oni (fi)
C&L Inventory
4-metüülpentaan-2-oon (et)
C&L Inventory
4-méthylpentane-2-one (fr)
C&L Inventory
4-μεθυλοπενταν-2-όνη μεθυλισοβουτυλοκετόν (el)
C&L Inventory
4-мeтилпентан-2-oн (bg)
C&L Inventory
hekson (pl)
C&L Inventory
isobutyl(methyl)keton (cs)
C&L Inventory
Isobutüülmetüülketoon (et)
C&L Inventory
izobutil-metil-keton (hr)
C&L Inventory
izobutilmetilcetona (ro)
C&L Inventory
izobutilmetilketonas (lt)
C&L Inventory
izobutilmetilketons (lv)
C&L Inventory
izobutyl(metyl)ketón (sk)
C&L Inventory
keton izobutylowo-metylowy (pl)
C&L Inventory
methylisobutylketon (da)
C&L Inventory
metil izobutil keton (sl)
C&L Inventory
metilisobutilcetona (es)
C&L Inventory
metilisobutilchetone (it)
C&L Inventory
metylisobutylketon (no)
C&L Inventory
metyyli-isobutyyliketoni (fi)
C&L Inventory
méthylisobutylcétone (fr)
C&L Inventory
изобутил метилкетон (bg)
C&L Inventory
2-Pentanone, 4-methyl-
Other
4-mehtylpentan-2-one
C&L Inventory
4-Methyl-2- Pentanone
C&L Inventory
4-METHYL-2-PENTANONE
C&L Inventory, Registration dossier
4-Methyl-pentan-2-on
C&L Inventory
4-methylpentan-2-ona
C&L Inventory
4-methylpentan-2-one isobutyl methyl ketone
C&L Inventory
4-metil-2-pentanone
C&L Inventory
4-metilpentan-2-one
C&L Inventory
Isobutyl methyl ketone, Isopropylacetone, MIBK, Methyl isobutyl ketone, 4-Methyl-2-pentanone
Registration dossier
Isobutylmethylketone
C&L Inventory
Methyl Isobuthyl Ketone
Registration dossier
methyl isobutyl cetone (MIBK)
Registration dossier
Methyl isobutyl ketone / MiBK
Registration dossier
methyl isobutyl ketone; MIBK
Registration dossier
Methyl isobutylketone
C&L Inventory
methyl isotutyl cetone
C&L Inventory
methylisobutylketone
C&L Inventory
MIBK
C&L Inventory, Registration dossier
Reaction mass of 108-88-3 and 78-83-1
C&L Inventory
Reaction mass of butan-2-ol and n-butyl acetate and 52350-17-1
C&L Inventory
UPV17
C&L Inventory
108-10-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. ADN Dangerous Goods Lists, Directive 2008/68/EC, EU. ADR Dangerous Goods Lists, Directive 2008/68/EC, EU. RID Dangerous Goods Lists, Directive 2008/68/EC, EU. Indicative OELVs - Directive 2000/39/EC, EU. Regenerated Cellulose Film Substances, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
1338234-91-5
CAS number
Other
606-004-00-4
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 2 studies processed
R Melting / freezing point
-84.7 - -84 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-84 °C

Boiling point

Study results
  • 2 studies submitted
  • 2 studies processed
R Boiling point
116 - 118 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
117 °C

Density

Study results
  • 2 studies submitted
  • 2 studies processed
R Density
0.798 g/cm³ @ 20 °C [1]
R Relative density
0.801 @ 20 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
797.8

Vapour pressure

Study results
  • 3 studies submitted
  • 2 studies processed
R Vapour pressure
20.932 - 26.4 hPa @ 20 - 25 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
26.4 hPa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Pow
79 @ pH 6.7 [1]
R Log Pow
1.9 @ pH 6.7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
14.1 g/L @ 20 °C and pH 5.4 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 3 studies submitted
  • 2 studies processed
R Flash point
18 - 23 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 3 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
448 - 460 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
460 °C

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
0.406 - 0.585 [5]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.585 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 600 µg/L (1)
Intermittent releases (freshwater) 1.5 mg/L (1)
Marine water 60 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 27.5 mg/L (1)
Sediment (freshwater) 8.27 mg/kg sediment dw (1)
Sediment (marine water) 830 µg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 1.3 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 179 mg/L [1]
NOEC (4 days) 179 mg/L [1]
LOEC (4 days) 179 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
179 mg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 200 mg/L [1]
NOEC (48 h) 200 mg/L [1]
LOEC (48 h) 200 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
200 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 30 - 78 mg/L [3]
LOEC (21 days) 64 - 156 mg/L [3]
EC50 (24 h) 3.623 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
30 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
146 mg/L
EC10 or NOEC for freshwater algae
146 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 146 mg/L [2]
NOEC (7 days) 146 mg/L [2]
LOEC (7 days) 146 mg/L [2]
EC10 (7 days) 146 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
146 mg/L
EC10 or NOEC for freshwater plants
146 mg/L

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
275 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 83 mg/m³ -
Acute /short term: (DNEL) 208 mg/m³ -
Local Effects
Long-term: (DNEL) 83 mg/m³ -
Acute /short term: (DNEL) 208 mg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11.8 mg/kg bw/day -
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: No hazard identified
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 14.7 mg/m³ -
Acute /short term: (DNEL) 155.2 mg/m³ -
Local Effects
Long-term: (DNEL) 14.7 mg/m³ -
Acute /short term: (DNEL) 155.2 mg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.2 mg/kg bw/day -
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary)
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.2 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 11.6 mg/L air (rat) [1]
LC50 (4 h) 2 000 - 4 000 ppm (rat) [1]
M/CInterpretations of results
Toxicity Category IV [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD0 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 2 080 mg/kg bw
Inhalation route:
Adverse effect observed Discriminating conc. 8 200 mg/m³
Dermal route:
No adverse effect observed Discriminating dose 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rat): 250 mg/kg bw/day [1]
LOAEL (rat): 1 000 mg/kg bw/day [1]
NOEL (rat): 50 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 8 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 450 ppm [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 250 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 1 843 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 6 146 mg/m³ (subchronic, rat)

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant