Substance Information

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REACH Registration data can be found in the new ECHA CHEM database. The old ‘Registered substance factsheets’ will be available on this web site during the transition period but have not been updated since 19 May 2023. More

 

1,4-dioxane

EC / List no.: 204-661-8

CAS no.: 123-91-1

Mol. formula: C4H8O2

formula
GHS02: Flammable GHS08: Serious Health Hazard GHS07: Health hazard

Danger! According to the harmonised classification and labelling (ATP17) approved by the European Union, this substance may cause cancer, is a highly flammable liquid and vapour, causes serious eye irritation and may cause respiratory irritation.

  • C

Carcinogenic

  • PBT

Possibly Persistent, Bioaccumulative and Toxic

  • Substance of very high concern (SVHC) and included in the candidate list for authorisation.

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses

ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Article service life

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
This substance can be found in products with material based on: rubber used for articles with intense direct dermal (skin) contact during normal use (e.g. gloves, boots, clothing, rubber handles, gear lever, steering wheels).

Widespread uses by professional workers

This substance is used in the following products: laboratory chemicals and pH regulators and water treatment products.
This substance is used in the following areas: scientific research and development and health services.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

Formulation or re-packing

ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Release to the environment of this substance can occur from industrial use: formulation of mixtures.

Uses at industrial sites

This substance is used in the following products: polymers, pH regulators and water treatment products, laboratory chemicals, lubricants and greases and pharmaceuticals.
This substance has an industrial use resulting in manufacture of another substance (use of intermediates).
This substance is used for the manufacture of: chemicals and plastic products.
Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and in the production of articles.

Manufacture

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

The InfoCard summarises the non-confidential data on substances as held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The InfoCard is automatically generated. Information requirements under different legislative frameworks may therefore not be up–to–date or complete. Substance manufacturers and importers are responsible for consulting official publications. This InfoCard is covered by the ECHA Legal Disclaimer.

ECHA logo about INFOCARD - Last updated: 06/09/2023