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EC number: 907-349-6
CAS number: -
Male and female ICR mice were exposed to
0.5, 2.5 or 5 ml/kg of octadecyl isocyanate which was administered as a
single i.p. injection. Bone marrow cells, collected 24, 48 and 72 hours
after treatment, were examined microscopically for micronucleated
polychromatic erythrocytes (equivalent to OECD TG 474; Putman 1989). No
change in the ratio of polychromatic erythrocytes to total erythrocytes
was observed in male or female mice in the test article treated
groups,suggesting that the test article did not induce bone marrow
toxicity. No significant increases in micronucleated polychromatic
erythrocytes were observed at 24, 48 or 72 hours after dose
administration in males or females. The results of the assay indicate
that under the conditions described, octadecyl isocyanate did not induce
a significant increase in micronucleated polychromatic erythrocytes in
male or female ICR mice. Therefore, octadecyl isocyanate was concluded
to be negative in the mouse micronucleus assay.
Not classified under Annex I of Directive 67/548/EEC. According to Annex
I of Regulation (EC) No 1272/2008 no classification is required for
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