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EC number: 907-349-6
CAS number: -
Erythema and edema were absent at 4 and 24 hours but increased
significantly by 72 hours. Erythema was well defined to moderate at 72
hours and on days 7 and 14. In addition, the reactions were generalized
over a large area of the skin of the animals. Instances of epidermal
cracking and fissuring, poor hair regrowth and areas of shiny skin were
also noted. Edema was well defined to severe by 72 hours and was also
generalised over a large area of the skin. In some instances the edema
extended beyond the exposed site but was not raised greatly. Yellow
nasal discharge was noted in one animal at 24 and 72 hours. There were
no abnormal systemic signs noted in the remaining five animals.
In a dermal irritation study according to EPA OPP 81-5 octadecyl
isocyanate was applied under occlusive dressings for 4 hours to the
shaved skin of 6 rabbits. Skin irritation was assessed after 4, 24, 72
hours and 7 and 14 days using the Draize scale. The modified primary
irritation index was 1.93 of max. 4. According to EPA criteria, the test
article is considered to be Category IV (mild or slight irritation).
However, the reactions noted at 72 hours and on days 7 and 14 indicate
that octadecyl isocyanate can produce delayed skin reactions of a severe
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