Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Principles of method if other than guideline:
Organisation for Economic Co-operation and Development
(OECD), OECD Guidelines for Testing of Chemicals, Section 4,
Health Effects, No. 402, "Acute Dermal Toxicity", Paris
Cedex, 1987.


European Community (EC), Council Directive 67/548/EEC, Annex
V, Part B, Methods for the determination of Toxicity, as
last amended by Commission Directive 92/69/EEC, B.3: "Acute
Toxicity (Dermal)". Official Journal of the European
Communities No. L 383, 1992.


United States Environmental Protection Agency (EPA). Health
Effects Test Guidelines, OPPTS 870.1200, Acute Dermal
Toxicity. Office of Prevention, Pesticides and Toxic
Substances (7101), EPA 712-C-96-192, August 1998.


Japanese Ministry of Agriculture, Forestry and Fisheries
(JMAFF), 12 Nousan, Notification No 8147, November 2000;
including the most recent partial revisions.
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: Rat, Wistar strain, Crl:WI (Han)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
propylene glycol
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Piloerection and/or chromodacryorrhoea (snout) were noted among the animals on Day 1. No mortality occurred. Body weight loss was seen in all males and in 3/5 females during the first week of the stud
Gross pathology:
Effects on organs:
No abnormalities were found at macroscopic post mortem
examination of the animals.
Other findings:
Signs of toxicity (local):
Scales and/or scabs were seen in the treated skin-area of
the majority of animals during the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU