Registration Dossier
Registration Dossier
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EC number: 413-110-2 | CAS number: 135861-56-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not acutely toxic to fish at its limit of solubility in water medium.
Key value for chemical safety assessment
Additional information
The toxicity to aquatic fish (Onchorhynchus mykiss) has been determined on a very close analogue according to OECD Guideline 203 and EU Method C.1 and in compliance with GLP. As no mortality was observed at the limit test of 100 mg/L, it is considered that the tested substance has no effect to fish at its limit of solubility in water medium (0.2 mg/l). The substance was demonstrated not to be acutely toxic to fish (LC0 > 0.2 mg/l).
In addition a QSAR was performed as a supporting study for acute toxicity to fish using ECOSAR. The applicability domain is fulfilled and the prediction can be estimated as relatively reliable. The LC50/96h has been estimated to be 34 mg/l, which is much higher than the water solubility. Therefore it is considered that the substance is not acutely toxic to fish at its limit of solubility in water medium (LC50 > 0.72 mg/l).
The LC0 > 0.2 mg/l will be used to express the lack of toxicity of the substance to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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