Registration Dossier
Registration Dossier
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EC number: 406-030-4 | CAS number: 105812-81-5
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Contact with eyes : wash immediately with large amounts of water or normal saline. Keep eyelid open with the finger. Get medical advice.
Contact with skin : remove contaminated clothes and shoes immediately. Wash affected area with soap or mild detergent and large amount of water until no evidence of substance remains. Get medical advice if adverse symptoms will appear.
Ingestion : if swallowed wash mouth with water provided person if conscious. Get medical advice.
Inhalation : avoid breathing dusts that might be generated by handling of the product. Remove the person from the exposed area to fresh air immediately. Get medical advice if adverse symptoms will appear.
Contact with skin : remove contaminated clothes and shoes immediately. Wash affected area with soap or mild detergent and large amount of water until no evidence of substance remains. Get medical advice if adverse symptoms will appear.
Ingestion : if swallowed wash mouth with water provided person if conscious. Get medical advice.
Inhalation : avoid breathing dusts that might be generated by handling of the product. Remove the person from the exposed area to fresh air immediately. Get medical advice if adverse symptoms will appear.
Fire-fighting measures
Suitable extinguishing means: alcohol-resistant foam , CO2, dry powder, water spray.
Mean of extinguishing NOT to be used: not known.
Known hazards caused by combustion: thermal decomposition or combustion may generate toxic and hazardous fumes of COx, NOx and HF.
In case of fire: Advise compenent persons. Evacuate area. Wear full protective clothing and self-contained breathing apparatus approved NIOSH/MSHA (or equivalent) as appropriate for specific fire conditions.
Mean of extinguishing NOT to be used: not known.
Known hazards caused by combustion: thermal decomposition or combustion may generate toxic and hazardous fumes of COx, NOx and HF.
In case of fire: Advise compenent persons. Evacuate area. Wear full protective clothing and self-contained breathing apparatus approved NIOSH/MSHA (or equivalent) as appropriate for specific fire conditions.
Accidental release measures
Personal precautions: wear suitable protective clothing, eye/face protection goggles, mask complete of suitable filter protection. Avoid dust formation. Avoid breathing vapours, dust, gas. Mantain a well-ventilated area. Evacuate area.
Environmental precautions: collect and clean with plenty of water. Send to the storage waiting for disposal procedures. Mantain a well-ventilated area. Do not let the product enter drainage system, surface and ground-water and soil. Contact local authorities in case of environmental release.
Cleaning procedure to recover spilled material: Recover the substance for suction or other mechanical means and wash the area with plenty of water and detergents. Wear suitable protective clothing. Store the material into a company that specializes pending disposal. Containers must be cleaned up and disposed.
Environmental precautions: collect and clean with plenty of water. Send to the storage waiting for disposal procedures. Mantain a well-ventilated area. Do not let the product enter drainage system, surface and ground-water and soil. Contact local authorities in case of environmental release.
Cleaning procedure to recover spilled material: Recover the substance for suction or other mechanical means and wash the area with plenty of water and detergents. Wear suitable protective clothing. Store the material into a company that specializes pending disposal. Containers must be cleaned up and disposed.
Handling and storage
The substance is chemically transformed into another intermediate in the synthesis of a final Active Pharmaceutical Ingredient.
The substance must be handled in ventilated environment or with the appropriate local air extraction; minimize dust formation and avoid accumulation on surfaces; use antistatic equipment and clothing and prevent dust contact with possible ignition sources; avoid contact with eyes, skin and clothing. Remove contaminated clothes and wash thoroughly after handling.
Use container tightly closed and resistant, away from moisture and sunlight. Avoid contact with air and light. Properly label containers in case of pouring and clean external container surfaces with proper detergents and /or solvents.
The substance must be handled in ventilated environment or with the appropriate local air extraction; minimize dust formation and avoid accumulation on surfaces; use antistatic equipment and clothing and prevent dust contact with possible ignition sources; avoid contact with eyes, skin and clothing. Remove contaminated clothes and wash thoroughly after handling.
Use container tightly closed and resistant, away from moisture and sunlight. Avoid contact with air and light. Properly label containers in case of pouring and clean external container surfaces with proper detergents and /or solvents.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 3077
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Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 3077
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Marine transport (UN RTDG/IMDG)
- UN number:
- 3077
Shipping information
- Chemical name:
- (-)-trans-4-(4’-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine
- Labels:
- ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (-)-trans-4-(4’-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3077
Shipping information
- Chemical name:
- (-)-trans-4-(4’-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine
- Labels:
- ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (-)-trans-4-(4’-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine
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Exposure controls / personal protection
Eye and Face protection: Safety goggles
Respiratory protection: Dust mask with approved dust filter. Use only devices approved by the Competent Authorities such as NIOSH (USA) and CEN (EU)
Hands protection: Protective gloves. Make the choice of the glove material on consideration of the penetration times, rates of diffusion and degradation.
Other, body protection: Select the suitable protective equipment based on the activity of use and possible exposure.
Respiratory protection: Dust mask with approved dust filter. Use only devices approved by the Competent Authorities such as NIOSH (USA) and CEN (EU)
Hands protection: Protective gloves. Make the choice of the glove material on consideration of the penetration times, rates of diffusion and degradation.
Other, body protection: Select the suitable protective equipment based on the activity of use and possible exposure.
Stability and reactivity
Stable under normal storage conditions.
Avoid contact with water, alcohol, acids, bases and metal powders, oxidizing agents.
Keep away from source of ignitions.
Avoid contact with water, alcohol, acids, bases and metal powders, oxidizing agents.
Keep away from source of ignitions.
Disposal considerations
National laws on disposal must be considered, local and UE requirements for wastes recycling must be respected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
