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EC number: 406-030-4
CAS number: 105812-81-5
Signs of irritation during induction:
reactions of grade 2 were noted at 14 test skin sites 1 hr after patch
removal and 8 of grade 1 at 24 hr.
However, large areas of pale grey/green-coloured necrosis prevented
accurate evaluation of erythema during induction at several skin sites
at both the 1 -hr and 24 -hr observations. Other adverse dermal
reactions noted were small scattered areas of pale grey/green necrosis,
bleeding, small superficial scabs, hardened dark brown-coloured scabs,
dried blood and desquamation.
Evidence of sensitisation of each challenge concentration: 1/18
One test group animal was found dead on day 23 and another was killed
for humane reasons on day 23 owing to rectal prolapse. The absence of
these animals was considered not to affect the integrity of the study.
Small scattered areas of dermal necrosis, accompanied by thickening of
the skin, were noted at the test material challenge site of one control
group animal at the 24 and 48 hr observations. A small scab was also
noted at the test material site of one other control animal at these
times. These reactions were attributed to irritancy of the test material.
No skin reaction were noted at the test material challenge sites of any
other test or control group animal or at any vehicle control sites of
the test and control group animals.
Bodyweight gains of animal in the test group were comparable to those in
the control group.
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