Registration Dossier
Registration Dossier
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EC number: 700-464-0 | CAS number: 99591-74-9
Endpoint summary
Administrative data
Description of key information
Additional information
The carbon dioxide (CO2) evolution test (modified Sturm test) was performed with MMDS.
The test revealed 48 and 60% (mean of 54%) biodegradation of MMDS. As biodegradation of MMDS of at least 60% was not reached within a 10-day window, the criterion for ready biodegradability was not met. In the toxicity control, MMDS was found not to inhibit microbial activity.
Although the substance MMDS was tested in this study, one can assume that, based on the rapid hydrolysis, the biodegradation is actually the biodegradation of the hydrolysis products MDSA and formaldehyde.
QSAR calculations were applied to both hydrolysis products: formaldehyde showed ready biodegradability and for MDSA, no conclusion on biodegradability was possible as all models did not reveal the same results. However, from the biodegradation test of MMDS one can estimate the contribution of each of the hydrolysis products to the biodegradation. The biodegradation test on MMDS revealed 54% biodegradation based on CO2 evolution. Considering that additionally about 30-40% is incorporated into biomass (REACH Guidance Chapter R.7.9.4.1), this result of 54% indicates a nearly complete ultimate degradation of MMDS. Considering that MMDS hydrolyses into 2 molecules with equal carbon mass, this also implies that both hydrolysis products contribute significantly to the biodegradation.
For the CSA, the hydrolysis products will be considered instead of the substance MMDS. It is deemed acceptable to use the value ready biodegradable for formaldehyde. For MDSA, although the above considerations imply that both hydrolysis products biodegrade significantly, the QSAR models did not lead to a definite conclusion. As no conclusion could be reached, it was decided to apply the worst case result and consider MDSA as not readily biodegradable.
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