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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Fraunhofer IME

Test material

Constituent 1
Chemical structure
Reference substance name:
2-{phenyl[2-(tetradecanoyloxy)phenyl]methyl}phenyl tetradecanoate
EC Number:
941-526-9
Molecular formula:
C47H68O4
IUPAC Name:
2-{phenyl[2-(tetradecanoyloxy)phenyl]methyl}phenyl tetradecanoate
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): AVG-42
- Physical state: White powder

- Expiration date of the lot/batch: August 25, 2014
- Storage condition of test material: Dark and cool place, protected from light
- ThoD: 2.060 mg O2/mg

Study design

Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, non-adapted
Details on inoculum:
- Source of inoculum/activated sludge: sewage treatment plant Ruhrverband Kläranlage, Schmallenberg, Germany. Mainly fed with municipal wastewater
- Method of cultivation: samples were not washed with mineral medium after the arrival at the laboratory but kept aerobic until use
- Initial cell/biomass concentration: 29.6 mg dry mass/L
Duration of test (contact time):
28 d
Initial test substance concentrationopen allclose all
Initial conc.:
100 mg/L
Based on:
test mat.
Initial conc.:
167 mg/L
Based on:
ThOD/L
Parameter followed for biodegradation estimation
Parameter followed for biodegradation estimation:
O2 consumption
Details on study design:
TEST CONDITIONS
- Test temperature: 22 °C ± 1°C
- pH: 7.4-7.6
- pH adjusted: yes

CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes (sterilized with HgCl2)
- Toxicity control: yes
Reference substance
Reference substance:
benzoic acid, sodium salt
Remarks:
100 mg/L

Results and discussion

% Degradationopen allclose all
Parameter:
% degradation (O2 consumption)
Value:
22.3
Sampling time:
14 d
Remarks on result:
other: mean of 2 determinations
Parameter:
% degradation (O2 consumption)
Value:
33.2
Sampling time:
28 d
Remarks on result:
other: mean of 2 determinations

Any other information on results incl. tables

The biodegradation within the 10-day-window was 25 %. The 10-day-window starts at day 6 -7.

No significant abiotic degradation was noticeable after 28 days of incubation (--> 2%).

The biodegradation of the item mixture in the toxicity control was found to be 33% after 14 days of incubation. Thus, the demanded threshold value of 25 % is exceeded and the test item can be identified as non-toxic in a ready biodegradability test.

The reference item sodium benzoate was degraded to 81% within the first 14 days.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Interpretation of results:
other: not readily biodegradable
Conclusions:
AVG-42 is not readily biodegradable under the chosen test conditions.