Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-024-7
CAS number: 85408-62-4
The purpose of this study was to generate
preliminary information concerning the effects of MILLED SLI (76) on
male and female reproductive performance such as gonadal function,
mating behavior, conception and parturition.
Four groups of 12 males and 12 females were
treated by gavage with MILLED SLI (76) once daily. The dose levels were:
0 mg/kg bw/day (control group), 100 mg/kg bw/day, 300 mg/kg bw/day, and
1000 mg/kg bw/day. Males were treated over a 15-day pre-pairing period
and during the pairing period up to one day before necropsy. Females
were treated throughout the pre-pairing, pairing, gestation and
lactation period up to weaning on day 21 post partum. A standard dose
volume of 10 mL/kg body weight with a daily adjustment to the actual
body weight was used. Control animals were dosed with the vehicle alone
All animals survived until scheduled
necropsy, except one female at 1000 mg/kg, which died, possibly due to a
In males at 300 and 1000 mg/kg, mean food
consumption was slightly reduced. Additionally, mean body weights were
reduced from the pairing period until the end of the study, whereas no
clear dose-dependency was noted. Mean body weight gain was slightly
reduced and recovered in the after pairing period at 300 mg/kg but not
at 1000 mg/kg.
In females at 1000 mg/kg, mean food
consumption was slightly reduced during the treatment period. At 300
mg/kg mean food consumption was only reduced during the second week of
the lactation period. As a result, a slight transient reduction of mean
body weight gain was noted in the lactation period at both dose levels.
Mean body weights were similar in all groups at the end of the study.
The fertility rate was 100% in all groups.
At all dose-levels, there were no treatment-related effects on estrous
cycle, precoital time, mean duration of gestation, number of corpora
lutea and implantations, post-implantation loss, pup survival or litter
size from birth through to scheduled sacrifice on day 21 post partum.
No significant deviations in mean organ
weight of testes and epididymides were recorded which could be
attributed to the treatment with the test item, since lower mean
absolute weights of epididymides were considered to be in relation with
lower body weights and no test item-related histopathological findings
No test item-related histopathologic
findings were observed in the reproductive organs of either sex from the
No abnormal findings were noted for pups at
first litter check or during the lactation period. Sex ratios at first
litter check and on day 21 post partum were unaffected by treatment with
the test item. Mean pup weights on day 1 post partum and mean pup weight
development during the lactation period were unaffected by treatment
with the test item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again