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EC number: 287-024-7
CAS number: 85408-62-4
Table 1: Average Eye Irritation Scores
Table 2: Animal Body Weights
Vocalisation following dosing
Animal body weights (g)
In this study, where 6 rabbits received a single application of 100 mg
of the substance (47.5% pure), iris lesions and redness and chemosis of
the conjunctivae were seen. Blanching of the conjunctivae was seen in
all animals at Day 1, in two animals at Day 2, in three animals at Day
3, and one animal at Days 4 and 7. Corneal epithelial peeling was
observed in all animals on Days 1 and 2, in five animals at Days 3 and
4, and in four animals at Day 7. Other signs observed in some animals
included necrosis, pannus, and corneal neovascularisation. The average
Draize score is determined to be 2.0, however for redness and chemosis
of the conjunctivae the scores are higher. There was no pain response
in any of the animals, no clinical signs were observed and all animals
had healthy body weight gain.
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