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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance is a mild skin irritant and a severe eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
yes
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
24 hours
Observation period:
14 days
Number of animals:
6 (4 males and 2 females).
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
1.25
Max. score:
2
Reversibility:
fully reversible within: 5 days
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0.5
Max. score:
2
Reversibility:
fully reversible within: 72 hours

Acetone oxime moistened with physiological saline was also slightly irritating.

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acetone oxime is a mild skin irritant.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
100ml
Duration of treatment / exposure:
Single exposure
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
6 animals. The eyes of three additional animals rabbits were washed with room temperature distilled water approximately twenty seconds after test material administration.
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0.8
Max. score:
3
Reversibility:
not fully reversible within: 21 days
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0.6
Max. score:
2
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
2.3
Max. score:
3
Reversibility:
fully reversible within: 21 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
1.8
Max. score:
2
Reversibility:
fully reversible within: 7 days
Interpretation of results:
highly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acetone oxime gave rise to severe eye irritation.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In a reliable skin irritation study in rabbits the substance gave rise to only mild skin irritation which was fully reversible. In a reliable eye irritation study in rabbits the substance gave rise to severe eye irritation. The corneal effects were not fully reversible within the duration of the study (21 days).


Justification for selection of skin irritation / corrosion endpoint:
Only one study available

Justification for selection of eye irritation endpoint:
Only one study available

Effects on eye irritation: corrosive

Justification for classification or non-classification

The substance does not meet the criteria for classification for skin irritation. However it does meet the criteria for eye irritation, Eye Damage 1, H318.