Registration Dossier
Registration Dossier
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EC number: 204-820-1 | CAS number: 127-06-0
Endpoint summary
Administrative data
Description of key information
Additional information
A reliable short-term toxicity study with fish is available for acetone oxime. Gieger et al (1990) reports a 96hr LC50 for short term toxicity in fish of 558 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for acetone oxime.
No reliable long-term toxicity data are available for the toxicity of acetone oxime to fish. However supporting measured data are available for the analogue, butanone oxime, and included in the dossier. Kurume Laboratory (1998) provided a reliable (Klimisch 1) GLP compliant study following OECD 304 methods. Juvenile Medaka, Oryzias latipes, were exposed to the analogue, butanone oxime, in a flow-through system for 14 days. The 14-day LC50, based on mortality and NOEC, based on growth, are calculated to be >100 mg/L and 50 mg/L, respectively. Consequently, the NOEC value will be taken for the long-term toxicity to fish endpoint.
A reliable short-term toxicity study with invertebrates is not available for acetone oxime. However, a reliable (Klimisch 1) short-term toxicity study with invertebrates has been conducted the analogue, butanone oxime and is included in this dossier. Kurume Laboratory (1998) reports an EC50 for short term toxicity inDaphnia magnaof 201 mg/L. Consequently this value will be taken as the short-term toxicity in invertebrates endpoint for acetone oxime.
No reliable long-term toxicity data are available for the toxicity of acetone oxime to invertebrates. However measured data are available for the analogue, butanone oxime, and included in the dossier.
Kurume Laboratory (1998) conducted a reliable (Klimisch 1) GLP compliant study following OECD 211 methods with the analogue, butanone oxime. Daphnia magnawere exposed to nominal concentrations of 25, 50 and 100 mg/L of the test substance for 21 days under semi-static conditions. The 21-day NOEC, based on reproduction, was >100 mg/L. Therefore, this value will be taken as the long-term toxicity in invertebrates endpoint for acetone oxime.
A reliable toxicity study with algae is not available for acetone oxime. However, a reliable (Klimisch 1) toxicity study with algae has been conducted the analogue, butanone oxime and is included in this dossier. Kurume Laboratory (1998) conducted a reliable (Klimisch 1) GLP compliant study following OECD 201 methods with the analogue, butanone oxime. The algae,Scenedesmus capricornutum, were exposed to the test substance at nominal concentrations of 1.02, 2.56, 6.4, 16 and 40 mg/L for 72 hrs under static conditions. The 72-h EC50 was 11.8 mg/L, based on growth. The 72-hr NOEC was 2.56 mg/L, based on growth. Consequently these values will be taken as the toxicity in algae endpoint for acetone oxime..
A reliable toxicity study with microorganisms is not available for acetone oxime. However, a reliable toxicity study is available for the analogue, butanone oxime, and is included in this dossier. A reliable (Klimisch 2) study report fromBASF(1988) provided a 17hr EC10 of 177 mg/L for toxicity of the analogue, butanone oxime to Pseudomonas putida. Consequently, this study will be taken as the toxicity to microorganisms endpoint.
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