Registration Dossier
Registration Dossier
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EC number: 442-490-2 | CAS number: 871-70-5 EMEROX 118
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- OECD 406 (skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- 1,18-octadecanedioic acid
- EC Number:
- 442-490-2
- EC Name:
- 1,18-octadecanedioic acid
- Cas Number:
- 871-70-5
- Molecular formula:
- C18H34O4
- IUPAC Name:
- octadecanedioic acid
- Reference substance name:
- 1,18 Octadecanedioic acid
- IUPAC Name:
- 1,18 Octadecanedioic acid
- Details on test material:
- - Name of test material (as cited in study report): 1,18 Octadecanedioic acid
- Physical state: white solid
- Analytical purity: 100%
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other:
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: dermal
- Vehicle:
- other: corn oil
- Concentration / amount:
- Inductions: 30 %
Challenge: 30 %
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: corn oil
- Concentration / amount:
- Inductions: 30 %
Challenge: 30 %
- No. of animals per dose:
- 30
Results and discussion
Any other information on results incl. tables
All test animals and controls showed no skin effects (0%). Not sensitizing in guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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