Registration Dossier
Registration Dossier
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EC number: 618-920-1 | CAS number: 93280-40-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Divanadyl pyrophosphate
- EC Number:
- 407-130-0
- EC Name:
- Divanadyl pyrophosphate
- Cas Number:
- 65232-89-5
- Molecular formula:
- (VO)2P2O7
- IUPAC Name:
- Divanadyl pyrophosphate
- Details on test material:
- - Name of test material (as cited in study report): E-326 Catalyst
- Physical state: greyish-green powder
- Analytical purity: 100%
- Lot/batch No.: 3883559 A
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals Inc., Denver, Pennsylvania.
- Age at study initiation: young adults (at least 8 weeks old)
- Weight at study initiation: no data
- Housing: individually
- Diet: Lab Rabbit Chow HF (Purina #5326), 125 g/day while on test.
- Water: tap water, ad libitum.
- Acclimation period: 55 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 21 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: closely clipped
- Vehicle:
- physiological saline
- Controls:
- other: untreated skin of the same animals served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 grams per site; two intact sites per animal
- % coverage: at least 10 % of the body area
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.25 ml - Duration of treatment / exposure:
- 4 h
- Observation period:
- 3 days
- Number of animals:
- 6 (2 males, 4 females).
- Details on study design:
- TEST SITE
- Type of wrap if used: gauze and porous tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess test material was removed using dry gauze.
- Time after start of exposure: 4 h
SCORING SYSTEM: draize score
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h - 48 - 72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
Any other information on results incl. tables
Erythema findings: right front/left front:
| Time | animal 1 | animal 2 | animal 3 | animal 4 | animal 5 | animal 6 |
| 0,5 h | 1/0 | 0/1 | 0/0 | 0/1 | 0/0 | 0/0 |
| 24 h | 0/1 | 0/0 | 0/0 | 0/1 | 0/0 | 0/0 |
| 48 h | 1/1 | 0/0 | 0/0 | 0/1 | 0/0 | 0/0 |
| 72 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Edema findings: right front/left front:
| Time | animal 1 | animal 2 | animal 3 | animal 4 | animal 5 | animal 6 |
| 0,5 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
| 24 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
| 48 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
| 72 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
