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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
See attached report in section 13.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Tungsten disilicide
EC Number:
234-909-0
EC Name:
Tungsten disilicide
Cas Number:
12039-88-2
Molecular formula:
Si2W
IUPAC Name:
tungsten disilicide
Test material form:
solid: particulate/powder

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
not possible to specify
No. with + reactions:
0
Total no. in group:
10
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
not possible to specify
No. with + reactions:
0
Total no. in group:
10
Reading:
other: negative control
Hours after challenge:
24
Group:
negative control
Dose level:
not possible to spcify
Remarks on result:
no indication of skin sensitisation
Reading:
other: positive control
Hours after challenge:
24
Group:
positive control
Dose level:
not possible to specify
Remarks on result:
other: not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
None of the tungsten substances in the category, tested for skin sensitization, produced evidence of skin sensitization.