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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tungsten disilicide
EC Number:
234-909-0
EC Name:
Tungsten disilicide
Cas Number:
12039-88-2
Molecular formula:
Si2W
IUPAC Name:
tungsten disilicide
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
300 mg tungsten disilicide/kg body weight
2000 mg tungsten disilicide/kg body weight
No. of animals per sex per dose:
6 femakle rats/ 300 mg tungsten disilicide/kg body weight
6 female rats/ 2000 mg tungsten disilicide/kg body weight
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50 cut-off
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed in rats treated with 300 and 2000 mg Tungsten Disilicide/kg body weight.
Clinical signs:
No clinical sign was observed in all the rats treated with 300 and 2000 mg tungsten disilicide/kg body weight.
Body weight:
Normal gain in body weight was observed in all the rats treated with 300 and 2000 mg tungsten disilicide/kg body weight.
Gross pathology:
External
External examination of terminally sacrificed rats did not reveal any abnormality.
Internal
Visceral examination of terminally sacrificed rats did not reveal any abnormality.
In absence of any pathological lesion in terminally sacrificed rats, it is concluded that the test item did not produce any treatment related effect at the dose level used in the present study.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
No mortality was observed in rats treated with 300 and 2000 mg tungsten disilicide/kg body weight. The acute oral LD50 (cut-off value) of tungsten disilicide in Wistar rats was found to be 5000 mg/kg body weight.
Executive summary:

EXECUTIVE SUMMARY:In an acute oral toxicity study, four sets of fasted Wistar rats (3 females/set) (8 to 10 weeks) were given a single oral dose oftungsten disilicideat 300mg/kg body weight (set I and II) and 2000 mg/kg body weight (set III and IV) and all rats were observed for 14 days.

There were no treatment-related mortality, clinical sign and changes in body weight or necropsy findings observed.

The acute oral median lethal dose (LD50cut-off value) oftungsten disilicideinWistar rats was found to be 5000 mg/kg body weight.

Based on the results of this study, an indication of the classification fortungsten disilicideisas follows:

Globally Harmonized System of Classification and

Labelling of Chemicals (GHS 2017)                         :          Category 5 or Unclassified