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EC number: 619-217-2
CAS number: 96487-85-3
The eye hazard potential of Norethyl
was assessed using the Bovine Corneal Opacity and Permeability test
(BCOP test) according to OECD guidelines and GLP principles. The
eye damage of Norethyl was tested through topical application for
approximately 240 minutes. The negative control responses of the
opacity and permeability values were less than the upper limits of the
laboratory historical rangeindicating that the negative control did not
induce irritancy on the corneas.The mean in vitro irritancy score
of the positive control (20% (w/v) Imidazole) was 113 and within the
historical positive control data range. It was therefore concluded that
the test conditions were adequate and that the test system functioned
Norethyl did not induce ocular irritation
through both endpoints, resulting in a mean in vitro irritancy score of
-1.1 after 240 minutes of treatment. Since Norethyl induced an IVIS ≤ 3,
no classification is required for eye irritation or serious eye damage.
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