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EC number: 500-147-5
CAS number: 61788-85-0
1 - 6.5 moles ethoxylated
Ab-sorbanceWell 1(Tissue 1/2)
Ab-sorbanceWell 2 (Tissue 1/2)
Mean Absor-bance (Tissue 1/2)
Mean Absorbance* Tissue 1 and 2
Mean Absorbance of2 Tissues*
Rel. Absorbance [%]Tissue 1 and 2**
Absolute Value of the Difference of the Rel. Absorbances [%]Tissue 1 and 2
Mean Rel. Absorbance
of two replicate wells after blank correction
absorbance [rounded values]: 100 * (absorbace test item/positive
control/negative control)/absorbance negative control
relative absorbance [rounded values]: 100
* (mean absorbace test item/positive control/negative control)/mean
absorbance negative control
eye irritation potential of the substance was assessed by means of the
Human Cornea Model Test. The
substance did not prove to be an MTT reducer and color interference was
50 µL of the test item, the negative control (deionised water) or the
positive control (methyl acetate) were applied to each of duplicate
tissue for 30 minutes.
treatment with the negative control the absorbance values were well
within the required acceptability criterion of OD > 0.8 and < 2.5 thus
showing the quality of the tissues.
with the positive control induced a decrease below 50% compared with the
negative control value in the relative absorbance thus ensuring the
validity of the test system.
difference of viability between the two relating tissues was < 20% in
the same run (for test item tissues, positive and negative control
effects were not observed following incubation with the substance.
Compared with the value of the negative control the relative mean
absorption value corresponding to the viability of the tissues did not
decrease below 60% (92.1%).
conclusion, it can be stated that in this study and under the
experimental conditions reported, the substance does not possess
any eye irritating potential.
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