Registration Dossier
Registration Dossier
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EC number: 807-113-1 | CAS number: 3709-71-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene
- Cas Number:
- 3709-71-5
- Molecular formula:
- C6F12
- IUPAC Name:
- (E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 18.2 mg/l (mean value, sd 2.80)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 18.2 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Zero
- Clinical signs:
- other: Some signs attributed to the restraints. In addition, increased respiratory rates during and one hour after exposure. After one day animal had hunched posture, increased respiratory rates and in one case strained head (unclear if these are restraint relat
- Body weight:
- Variations not considered significant.
- Other findings:
- Dark patches observed on the lungs of females during necropsy.
Applicant's summary and conclusion
- Conclusions:
- It is considered reasonable that ... [the substancer] does not meet the criteria for classification and will not require labelling for inhalation toxicity.
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