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EC number: 234-282-3
CAS number: 11065-74-0
The study was carried out based on the
guidelines described in:
- OECD No.423 (2001) "Acute Oral Toxicity,
Acute Toxic Class Method"
- Commission Regulation (EC) No 440/2008, B1
tris: "Acute Oral Toxicity, Acute Toxic Class Method"
- EPA, OPPTS 870.1100 (2002), "Acute Oral
- JMAFF guidelines (2000) including the most
recent partial revisions.
EDTA-MnNa2 was administered by oral gavage
to two subsequent groups of three female Wistar rats at 2000 mg/kg body
weight. Animals were subjected to daily observations and weekly
determination of body weight. Macroscopic examination was performed
after terminal sacrifice (Day 15).
No mortality occurred. Piloerection or
hunched posture were noted in all animals on Day 1. The body weight gain
shown by the animals over the study period was considered to be similar
to that expected of normal untreated animals of the same age and strain.
No abnormalities were found at macroscopic post mortem examination of
the animals. The oral LD50 value of EDTA-MnNa2 in Wistar rats was
established to exceed 2000 mg/kg body weight. According to the OECD 423
test guideline, the LD50 cut-off value was considered to exceed 5000
mg/kg body weight.
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