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EC number: 208-589-8
CAS number: 534-15-6
Embryos cultured in the presence of Propylal at doses up to
1000 μg/mL exhibited no adverse effect on embryonic growth, development
or morphology. Findings at 1 μg/mL were not attributed to treatment.
Embryos cultured in the presence ofPropylalat doses
up to 1000 μg/mL exhibited no adverse effect on embryonic growth,
developmentor morphology. Morphological
observations were generally of a minor nature and were therefore
Low incidences of minor
morphological observations were recorded; these were mostly haemorrhages
and common pericardial defects, which were considered unlikely to be
related to treatment.
preliminary study cultures started on 19 April 2016, stoppers had fallen
out of four bottles prior to the start of culture. The
medium within these bottles appeared bright pink. Since
there was insufficient time to prepare fresh medium these bottles were
assigned to the lowest concentration level for material dosed on that
seen could be attributed to the change in the culture medium as they
were not seen at the higher dose levels; hence for propylal, findings
at 1 μg/mL were not attributed to treatment
other effects were seen following treatment with propylal, hence this
material was considered not to show developmental toxicity in vitro.
The influence of Propylal, upon
growth and development in vitro was assessed in Day 9.5 embryos from
rats of the CD strain. Each test substance was added
to the culture medium at concentrations of 1, 10, 100 and 1000 mg/mL
in groups of 3 embryos in the preliminary study. In
the main study groups of 7 embryos were administered each test substance
at concentration levels of 30, 100, 300 and 1000mg/mL. The
negative Control group received the vehicle corn oil at the same
volume-dose. All embryos were evaluated after
approximately 48 hours in culture.
No adverse effect on embryonic growth, development or morphology was
observed at doses up to 1000 μg/mL.
It was observed from this
exploratory investigation that embryos cultured in the presence of
propylal exhibited no adverse effects on growth, development or
morphology. It was concluded, therefore, that propylal showed no
potential embryo toxicity or teratogenicity.
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