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EC number: 208-589-8
CAS number: 534-15-6
The study was performed to assess the acute oral toxicity of the test
item in the Wistar strain rat.
Following a sighting test at a dose level of 2000 mg/kg, an additional
four fasted female animals were given a single oral dose of the
undiluted test item, as supplied, at a dose level of 2000 mg/kg body
weight. Clinical signs and body weight development were monitored during
the study. All animals were subjected to gross necropsy.
Mortality. One animal was humanely killed one hour after dosing as it
was considered to have exceeded the severity limit set forth by the UK
Clinical Observations. Signs of systemic toxicity noted during the day
of dosing included hunched posture, prostration, decreased and labored
respiration, dehydration, and coma.
Body Weight. All surviving animals showed expected gains in body weight.
Necropsy. Abnormalities noted at the necropsy of the animal that was
humanely killed during the study included a renal cavity in the left
kidney and pale and thickened gastric mucosa. No abnormalities were
noted at the necropsies of the animals that were killed at the end of
The acute oral median lethal dose (LD50) of the test item in the female
Wistar strain rat was estimated to be greater than 2000 mg/kg body
weight (Globally Harmonized Classification System — Category 5).
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