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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
ca. 0.542 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 g/L
Temp.:
20 °C
pH:
9.9
Water solubility:
4.94 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
10 g/L
Temp.:
20 °C
pH:
10.8
Conclusions:
The water solubility of the test item at 20.0 ± 0.5 °C has been demonstrated to be loading rate dependent, as shown in the following table:
Nominal Loading Rate (g/L) Concentration (g/L) Percentage of Loading Rate (%)
1 0.542 58.5
10 4.94 49.0
25 11.9 47.0

As the solubility of the test item was loading rate dependent, a single definitive value was not possible.

Description of key information

Demonstrated to be loading rate dependent at 20.0 ± 0.5 °C using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995, as shown in the following table:

Nominal Loading Rate (g/L)       Concentration (g/L)       Percentage of Loading Rate (%)

1                                                 0.542                                 58.5

10                                               4.94                                   49.0

25                                               11.9                                   47.0

As the solubility of the test item was loading rate dependent, a single definitive value was not possible.

Key value for chemical safety assessment

Additional information