Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vivo, other
Type of information:
other: Expert assessment
Adequacy of study:
weight of evidence
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An assessment was performed based on the toxicokinetics behaviour of the substance and the available information on its degradation products

Data source

Reference
Reference Type:
other: Expert Assessment
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
An assessment was performed based on the toxicokinetics behaviour of the substance and the available information on its degradation products
GLP compliance:
no
Type of assay:
other: An assessment was performed based on the toxicokinetics behaviour of the substance and the available information on its degradation products

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl chloroacetate
EC Number:
219-834-3
EC Name:
Vinyl chloroacetate
Cas Number:
2549-51-1
Molecular formula:
C4H5ClO2
IUPAC Name:
ethenyl 2-chloroacetate
Test material form:
liquid

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
other: An assessment was performed based on the toxicokinetics behaviour of the substance and the available information on its degradation products
Toxicity:
not specified
Remarks:
An assessment was performed based on the toxicokinetics behaviour of the substance and the available information on its degradation products

Applicant's summary and conclusion

Conclusions:
Based on the result of the toxicokinetics behaviour of vinyl chloroacetate and the well documented in vivo mutagenic effects of acetaldehyde, it is concluded that vinyl chloroacetate will be mutagenic in vivo on account of this degradation product and should receive the same proposed classification as acetaldehyde for mutagenicity: Muta. 2, H341.
Executive summary:

A hydrolysis study was performed on vinyl chloroacetate, in accordance with the OECD Guideline 111, for the purposes of REACH registration. The half-lives (1.22 hours at pH 7 and 3.92 hours at pH 4) indicate that the substance is unstable and will undergo rapid hydrolysis. The rate of hydrolysis is faster at neutral and high pH ranges but still occurs at a rapid rate under acidic conditions. Therefore hydrolysis of vinyl chloroacetate is expected to occur rapidly following oral exposure. Since the hydrolysis tests were performed at 20°C, hydrolysis may be expected to occur at a faster rate following exposure on account of the higher temperature (~37 °C) in the body.  

Two main degradation products were obtained in the study and identified as acetaldehyde (CAS 75-07-0 / EC 200-836-8) and chloroacetic acid (CAS 79-11-8 / EC 201-178-4). Considering the short half-life of vinyl chloroacetate, it can be expected that the degradation products will form rapidly in the body. Therefore it is likely that the mutagenic effect of the substance will be as a result of its degradation products in vivo.

Based on the result of the toxicokinetics behaviour of vinyl chloroacetate and the well documented in vivo mutagenic effects of acetaldehyde, it is concluded that vinyl chloroacetate will be mutagenic in vivo on account of this degradation product and should receive the same proposed classification as acetaldehyde for mutagenicity: Muta. 2, H341.