(4'-methyl-3-fluoro[1,1'-biphenyl]-4-yl)-boronic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07.09.2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction

Deviations:

no

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Key result

Percentile:

D50

Mean:

16 µm

Remarks on result:

other: no SD indicated

Key result

Percentile:

D10

Mean:

4 µm

Remarks on result:

other: no SD indicated

Key result

Percentile:

D90

Mean:

44 µm

Remarks on result:

other: no SD indicated

The test item consisted of crystalline particles which appear partially broken and partially rod-shaped. The particles were introduced to the analyse beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar_g ). After passing the analyser beam the sample was collected with a vacuum cleaner.

After adjusting the laser, measuring the background and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 8 s. Median values were calculated from unrounded values.

 

The median particle size L50 (D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: L50 = 16.1 μm

2nd test series: L50 = 16.2 μm

The average of the median particle size L50 was: L50 = 16.2 μm

 

The particle size L10 (D (v, 0.1 ): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: L10 = 3.9 μm

2nd test series: L10 = 3.9 μm

The average of the particle size L10 was: L10 = 3.9 μm

 

The particle size L90 (D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: L90 = 43.3 μm

2nd test series: L90 = 43.9 μm

The average of the particle size L90 was: L90 = 43.6 μm

The particle size distribution showed a polymodal distribution with two maxima. The first maximum was observed at approx. 20 µm and second at approx. 300 µm. A shoulder was observed at approximately 300 μm.

Conclusions:

The median particle size L50 of the test item deduced from the particle size distributions was16 µm.

Executive summary:

The particle size distribution of the test item is determined by laser diffraction (light scattering) according to OECD Guideline OECD 110. The particle size distribution showed a polymodal distribution with two maxima. The first maximum was observed at approx. 20 µm and second at approx. 300 µm. A shoulder was observed at approx. 300 µm. The mean particle size D50 of the test item was 16 µm.

Description of key information

The particle size distribution of the test item is determined by laser diffraction (light scattering) according to OECD Guideline OECD 110. The particle size distribution showed a polymodal distribution with two maxima. The first maximum was observed at approx. 20 µm and second at approx. 300 µm. A shoulder was observed at approx. 300 µm. The mean particle size D50 of the test item was 16 µm.