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EC number: 200-460-4
CAS number: 60-18-4
In the current study the potential of the test item L-Tyrosine to induce
gene mutations according to the plate incorporation test (experiment I)
and the pre-incubation test (experiment II) using Salmonella
typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA 102 was
assessed according to OECD TG 471 and in compliance to GLP.
In two independent experiments several concentrations of the test item
were used. Each assay was conducted with and without metabolic
activation. The concentrations, including the controls, were tested in
triplicate. The following concentrations of the test item were prepared
and used in the experiments: 31.6, 100, 316, 1000, 2500 and 5000 μg/plate
No precipitation of the test item was observed in any tester strain used
in experiment I and II (with and without metabolic activation).
No toxic effects of the test item were noted in any of the five tester
strains used up to the highest dose group evaluated with and without
metabolic activation in experiment I and II.
No biologically relevant increases in revertant colony numbers of any of
the five tester strains were observed following treatment with
L-Tyrosine at any concentration level, neither in the presence nor absence
of metabolic activation in experiment I and II.
In conclusion, it can be stated that during the described mutagenicity
test and under the experimental conditions reported, L-Tyrosine did not
cause gene mutations by base pair changes or frameshifts in the genome
of the tester strains used. Therefore, L-Tyrosine is considered to be
non-mutagenic in this bacterial reverse mutation assay.
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