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EC number: 200-460-4
CAS number: 60-18-4
Two in vitro studies were set up: a DPRA and a KeratinoSens study.
During the preliminary studies proceeding the main in vitro test, it was
however found that the test item, L-tyrosine, is insufficiently soluble
in any of the solvents applicable for these two tests at the required
concentration level. Consequently, the main tests could not be performed.
Due to the technical limitations occuring in the DPRA and the
KeratinoSens study, in vitro skin sens testing was not possible.
L-tyrosine is an essential amino acid and the precursor to the natural
skin pigment melanin. As such, tyrosine is ubiquitously present in (and
on) the human skin, and is not expected to exert skin sensitizing
effects. Based on this information, and for reasons of animal welfare,
additional in vivo testing of the skin sensitizing properties of
L-tyrosine is not deemed necessary.
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