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EC number: 200-460-4
CAS number: 60-18-4
In Vitro Irritation Score
MV: Mean Value
In the current study the eye irritation potential of the test item L-Tyrosine
was investigated in the bovine corneal opacity and
permeability assay. The test was performed according to OECD 437
and in compliance to GLP.
The in vitro irritation score obtained with the positive
control fell within the two standard deviations of the current
historical mean and therefore this assay is considered to be valid.
The negative control responses resulted in opacity and
permeability values that are less than the established upper limits for
background bovine corneas treated with the respective negative control.
Thus the acceptability criteria were fullfilled and the
validity of the test system was confirmed.
The test item was suspended with physiological saline 0.9% NaCl to
obtain a 20% concentration.
All 3 corneas treated with L-Tyrosine showed no opacity of the
tissue but the test item bequeathed
few white spots.
The following mean in vitro irritation score was calculated:
Therefore the test item was classified into UN GHS No Category.
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