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EC number: 200-460-4
CAS number: 60-18-4
In the current study the effect of a single oral administration of a
high dose of tyrosine was investigated. More in detail the behavior of
the rats was evaluated with a computer pattern recognition system. The
study was not according to OECD or GLP, however, the animals were
observed for 2 weeks. There were 2 dosing groups, 309 and 618 mg/kg,
each containing 15 animals and each group was linked to a control group
of 15 animals. Amphetamine was used as positive control.
No animals died and no adverse effects were observed during the course
of the study. Amphetamine clearly increased the total time the rats
engaged in walking, turning, and head turning, and thus influenced the
No LD50 was determined in the study, however, we can derive it and state
that the LD50 is > 618 mg/kg bw.
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