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EC number: 214-275-1
CAS number: 1119-34-2
The acute oral toxicity of L-argine-HCl was investigated with
Sprague-Dawley rats. Test item was administered at two dose levels of 10
and 20% (w/v) in distilled water (five males and five females per
group). After 72 hours, neurological parameters like ataxia or sleeping
time were observed and the number of dead was counted and analyzed by
the method of Litchfield and Wilcoxon.Some signs of toxicity were
reported such as ataxia, dyspnea, decreased muscle tonus, and loss of
righting reflex. Toxicity signs were first observed 11 g/kg bw. LD50 of
L-argine-HCl was determined to be 12400 mg/kg b.w.
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