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EC number: 211-189-6
CAS number: 632-99-5
In a Repeated dose toxicity study for
Magenta was conducted in male and female Syrian golden Hamster for 88
weeks by oral gavage.The animals were exposed twice weekly to 0,400 and
600 mg/kgbw/dayoftest substance. In high dose level groups 600 mg/kg
b.w. the majority of animals died within the first 10 weeks of
treatment.They showed a rapid weight loss, haemorrhagic enteritis,
stomach ulcers, and diarrhoea. The data clearly indicate that these dose
levels were not tolerated by the Syrian golden hamsters. On the other
hand, the lower doses (400 mg/kg was well-tolerated and the body weight
developments of these groups were similar to those of the controls, as
were the average survival times. Macroscopic alterations and microscopic
lesions were similar in experimental and control hamsters, and were not
associated with treatment. Age-dependent alterations included
amyloidosis of the kidneys, liver and spleen. The overall tumor
incidences was 5%;. Average survival times of tumor bearing animals was
68 weeks while NaCl controls, 55 weeks. The urinary tract was free of
neoplastic growth.Tumors found in the treated groups and not seen the
controls were either isolated observations or known from historic
controls.As no significant effect were observed at the doe level of
400mg/kgbw/day. Therefore NOAELwas considered to be 400mg/kgbw/day for
Magenta in male and female Hamster by oral gavage for 88 weeks.
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