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EC number: 267-956-0
CAS number: 67953-76-8
In accordance with Column 2 of REACH Annex IX, there is no need to
further investigate the effects of this substance in a long-term
terrestrial toxicity to higher plants study because:
• The substance is involatile and highly adsorbing and low toxicity was
observed in the available pelagic organism and aquatic microorganism
tests, and there is no reason to expect effects in the terrestrial
compartment that were not expressed in the aquatic compartment.
• Based on the aquatic data set, the most sensitive relevant trophic
level is invertebrates. A long-term earthworm reproduction test for a
closely related substance within the HEDP category is already available,
and low toxicity was observed (NOEC 500 mg/kg active acid, Noack, 2014).
• The soil hazard category 3 (ECHA guidance part R7(c) table R.7.11-2)
applies for this substance. According to the specified approach for soil
hazard category 3 substances, if PEC/PNEC screen <1 and there is no
indication of risk from confirmatory long-term soil toxicity testing
then no further toxicity testing for soil organisms is necessary, as has
been demonstrated for this substance.
• The phosphonate ligand binds strongly and irreversibly to various
minerals present in soil and so bioavailability to soil organisms is
The terrestrial chemical safety assessment has been conducted using the
Equilibrium Partitioning method (EQPM).
It is recognised that the aquatic PNEC used in the EQPM does not
take into account any indicator for effects in aquatic microorganisms.
However, a reliable study of the effects on anaerobic sewage treatment
plant micro-organisms with HEDP-H records a lack of effects on bio-gas
production up to at least 200 mg active acid/l (Henkel, 1972). A study
with HEDP-xNa determined an IC0 value of >250 mg/l for the
effects on bioluminescence with the bacterium Photobacterium
phosphoreum (Grohmann and Horstman, 1989). Another study with
HEDP-H, on aerobic sewage treatment plant micro-organisms, indicates a
lack effects on MBAS reduction of up to 300 mg active acid/l after 53
days exposure in a simulation study (Henkel, 1972). These studies
demonstrate the low toxicity of HEDP and its salts to micro-organisms.
See Section 6.1.7 for further details.
These results show a similar level of effect to that observed in the
lowest reliable short-term aquatic toxicity study with fish, where a
96-h LC50 value of 195 mg active acid/L with Salmo
gairdneri was determined (EG&G, 1976).
The data on long-term ecotoxicity to fish and invertebrates also suggest
that aquatic microorganisms are comparatively less sensitive, where the
lowest reliable long-term toxicity NOEC value was observed with
invertebrates at 6.25 mg active acid/L.
Therefore it is unlikely that the PNECterrestrial based on aquatic
ecotoxicity test results would not be protective for terrestrial
The chemical safety assessment using EQPM does not suggest any
unacceptable risks for the terrestrial compartment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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