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EC number: 436-100-1
CAS number: -
Maximum concentration not causing irritating effects in preliminary test: 10 %Signs of irritation during induction:At 50% SNEA, discrete to moderate erythema was noted and 7animals had hard skin or scabbing at the test site. In week2 (25% SNEA), discrete to moderate erythema and scabbing,dry, flaky or hard skin was noted. At week 3 (10% SNEA),discrete to moderate erythema was noted.Evidence of sensitisation of each challenge concentration:Positive responses were noted in the majority of test groupanimals. Reactions were either discrete or patchy erythema(1) or moderate and confluent erythema (2). No positiveresponses were observed in control group animals.Other observations:Dose Ranging for Induction and Challenge: Ca. 24h after atopical application of 2000 mg/kg, the animals were humanelykilled. The animals were found lying on their sides atmorning check. They could not move around nor stand, werecold to touch and breathing was laboured. Aminals wereconstantly trying to stand up. Bodyweights had decreased.At the 1000 mg/kg dose level (topical), the animalsdemonstrated laboured breathing, locomotion difficulties andwere cold to touch 24 h after application. Based on thesereactions, the Buehler Test method was used.Main Study: In the second induction, dark extremities andhead tremors were observed.
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